Chinese translation Background: Many patients with rheumatoid arthritis (RA) do not
achieve adequate and safe responses with disease-modifying antirheumatic drugs (DMARDs). …

Objective Recent genome-wide association studies suggested the PRDM1-ATG5 gene
region as a systemic lupus erythematosus (SLE)-associated locus both in Caucasian and …

Objective. To investigate the prevalence of eight common rheumatic diseases in a large
Chinese population. Methods. A population-based epidemiological investigation of the …

Objective. To explore the potential role of Dickkopf-1 (DKK-1) in rheumatoid arthritis (RA)
and to evaluate the effect of a tumor necrosis factor-α (TNF-α) inhibitor (infliximab) and an …

Objective Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine
IL-17 have been demonstrated under normal and pathogenic conditions. However, it …

Background Systemic lupus erythematosus (SLE) is associated with significant impairment
of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low …

N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of
diseases and the therapeutic functions of antibody-based drugs; however, low-abundance …

About 2500 years ago, gout was observed by Hippocrates and many people suffered severe
pain and deformity. Lifestyle and diet play a significant role in gout and serum uric acid …

Background Treat-to-target strategies have improved outcomes in single-organ diseases
with simple clinical or laboratory endpoints. A lack of validated endpoints has prevented …

Objective. Interleukin 33 (IL-33) is a novel cytokine involved in joint inflammation in animal
models. We analyzed the expression of IL-33 in the serum and synovial fluid of patients with …