Introduction Chloroquine and hydroxychloroquine are widely used in the long-term treatment
of connective tissue disease and usually considered safe. However, chloroquine- or …

Epigenetic abnormalities are part of the pathogenetic alterations involved in the development
of rheumatic disorders. In this context, the main musculoskeletal cell lineages, which are …

Although this phase I study included a limited number of patients without a placebo arm, it
showed that local injection of autologous adipose-derived stem cells was safe and well …

During the past 20 years, the development of telemedicine has accelerated due to the rapid
advancement and implementation of more sophisticated connected technologies. In …

Introduction Recent evidence suggests that tissue accumulation of senescent p16 INK4a -positive
cells during the life span would be deleterious for tissue functions and could be the …

Importance One-third of patients with rheumatoid arthritis show inadequate response to tumor
necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists. …

Objective. The objective of this study was to identify predictors of response and remission to
tocilizumab (TCZ) in RA patients seen in daily routine clinical practice. Methods. The efficacy …

Background The high number of survivors from the 2013–16 west African outbreak of Ebola
virus disease (EVD) has raised several new issues: long-term clinical complications, …

Although biologic therapies have changed the course of rheumatoid arthritis (RA), today’s
major challenge remains to identify biomarkers to target treatments to selected patient groups. …

Objective To evaluate the efficacy of tocilizumab, an antibody against IL-6 receptor, in patients
with hand osteoarthritis. Methods This was a multicentre, 12-week, randomised, double-…