Sirolimus (SRL) is a mammalian target of rapamycin inhibitor that, in contrast to cyclosporine
(CsA), has been shown to inhibit rather than promote cancers in experimental models. At 3 …

ABSTRACT. Graft function at 6 or 12 mo is positively correlated with renal transplant survival.
The 36-mo results of a study that tested whether withdrawing cyclosporine (CsA) from a …

AIM A case-control study was initiated to determine the risk factors for the development of
age related macular degeneration (AMD). METHODS Study participants, who were all white, …

Graft function and histology are predictive of renal transplant survival. The Rapamune
Maintenance Regimen study demonstrated that early cyclosporine (CsA) withdrawal from a …

Introduction The Rheumatoid Arthritis Impact of Disease (RAID) is a patient-reported outcome
measure evaluating the impact of rheumatoid arthritis (RA) on patient quality of life. It …

The aim was to study the influence of sirolimus (SRL) on body weight in a rat model and in
kidney transplant patients. Wistar rats (15 weeks old) were either treated with vehicle (VEH; n …

Objective Post hoc analysis of pooled data from nine randomised controlled trials to assess
the effect of tofacitinib (oral Janus kinase inhibitor for treatment of rheumatoid arthritis (RA) …

Background: The efficacy of anxiolytic drugs in generalized anxiety disorder (GAD) is
conventionally assessed by evaluating changes in the total score of psychometric scales such as …

Objective We report the final analysis of the French ACROSTUDY, using data revised and
enriched since the 2013 interim analysis. Our objective was to validate the use of pegvisomant …

Sirolimus (SRL) has a concentration‐related effect on hematopoiesis. In this study, 430 renal
transplant recipients were randomized (1:1) 3 months post‐transplantation to continue SRL…