Cancer stem cells (CSCs) have been defined as a unique subpopulation in tumors that possess
the ability to initiate tumor growth and sustain tumor self-renewal. Although the evidence …

Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in familial
conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the cerebellum …

We have synthesized Co fine particles with the average diameter (D) of less than 500 Å by
sputtering Co in a somewhat high inert-gas pressure. It has been found that there is a close …

The 41-kDa and 43-kDa mitogen-activated protein (MAP) kinases play a pivotal role in the
mitogenic signal transduction pathway and are essential components of the MAP kinase …

Purpose: We performed a multicenter randomized controlled trial to determine whether
postoperative adjuvant chemotherapy improves outcome in patients with esophageal squamous …

Twenty‐one esophageal cancer cell lines (KYSE series) have been established from the
resected specimens of patients with esophageal cancer. Three lines, KYSE‐30, KYSE‐50, and …

Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a key regulator
of organ size and a candidate human oncogene located at chromosome 11q22. Since we …

A magnetic sheet made of Fe–Si–Al flakes was found to have excellent permeability and
electromagnetic-interferences characteristics in a quasimicrowave band. The flakes prepared …

Purpose: CC chemokine receptor 7 (CCR7) plays a critical role in the migration of activated
dendritic cells to regional lymph nodes. Recent studies have shown that CCR7 is involved in …

Gankyrin is an ankyrin repeat oncoprotein commonly overexpressed in hepatocellular
carcinomas. Gankyrin interacts with the S6 proteasomal ATPase and accelerates the degradation …