Basic fibroblast growth factor (FGF-2), an important modulator of cartilage and bone growth
and differentiation, is expressed and regulated in osteoblastic cells. To investigate the role of …

Bone homeostasis is maintained by a balance between bone resorption by osteoclasts and
bone formation by osteoblasts. Osteoblasts not only play a central role in bone formation by …

Background Fluctuations in blood glucose level cause endothelial dysfunction and play a
critical role in onset and/or progression of atherosclerosis. We hypothesized that fluctuation in …

Background Limited evidence suggests that multifactorial interventions for control of glucose,
blood pressure, and lipids reduce macrovascular complications and mortality in patients …

Background: Mönckeberg’s calcification in diabetes, known as medial artery calcification, is
an independent predictor of cardiovascular mortality. However, the mechanism underlying …

Objective Mesenchymal stem cells (MSCs) are considered to be a novel tool for the treatment
of rheumatoid arthritis (RA) because of their multipotency to differentiate into osteoblasts …

Although increased vascular permeability is known to be a major characteristic of diabetic
vasculopathy, the precise mechanisms and relevance of advanced glycation end products (…

We examined the effect on osteoclast formation of disrupting the prostaglandin G/H synthase
genes PGHS-1 and-2. Prostaglandin E 2 (PGE 2 ) production was significantly reduced in …

Introduction The aim of the present study was to determine the effect of sitagliptin on
microalbuminuria in patients with type 2 diabetes mellitus. Materials and Methods A total of 85 …

Prostaglandin E 2 (PGE 2 ) stimulates the formation of osteoclast-like tartrate-resistant acid
phosphatase-positive multinucleated cells (TRAP + MNC) in vitro. This effect likely results …