Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

…, A Yamamoto, T Miyazaki, Y Koshihara… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To clarify the mechanism by which osteoclasts are formed in culture of rheumatoid
synoviocytes by exploring the involvement of receptor activator of nuclear factor κB ligand (…

Caffeic acid is a selective inhibitor for leukotriene biosynthesis

K Yasuko, N Tomohiro, M Sei-Itsu, L Ai-Na… - … et Biophysica Acta (BBA …, 1984 - Elsevier
Leukotrienes are significantly involved in immunoregulation and in a variety of diseases,
including asthma, inflammation and various allergic conditions. They are initially …

Expression of mRNAs for neuropeptide receptors and β-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells

A Togari, M Arai, S Mizutani, S Mizutani, Y Koshihara… - Neuroscience …, 1997 - Elsevier
In human periosteum-derived osteoblastic cells (SaM-1) and human osteosarcoma-derived
cells (SaOS-2, HOS, MG-63), the mRNA expressions of calcitonin gene-related peptide …

A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis

…, S Tanaka, T Nishikawa, Y Koshihara - Biochemical and …, 1997 - Elsevier
Bone-resorbing multinucleated cells were efficiently formed in primary culture of cells isolated
from synovial tissues of patients with rheumatoid arthritis in 2-3 weeks in the presence of 1,…

Vitamin K2 Enhances Osteocalcin Accumulation in the Extracellular Matrix of Human Osteoblasts In Vitro

Y Koshihara, K Hoshi - Journal of Bone and Mineral Research, 1997 - academic.oup.com
The role of vitamin K in osteocalcin accumulation in the extracellular matrix of normal human
osteoblasts in culture was investigated by using a human intact osteocalcin‐specific assay …

Inhibitory effect of esculetin on 5-lipoxygenase and leukotriene biosynthesis

N Tomohiro, K Yasuko, M Sei-Itsu - … et Biophysica Acta (BBA)-Lipids and …, 1983 - Elsevier
Esculetin (6,7-dihydroxycoumarin) showed inhibitory effects on 5- and 12-lipoxygenases of
cloned mastocytoma cells. The half-inhibition dose (ID 50 ) for each enzyme was 4ˇ10 −6 and …

Regulation by PGE2 of the production of interleukin‐6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblasts

…, H Ishibashi, S Yamamoto, Y Koshihara - British journal of …, 2002 - Wiley Online Library
We examined the effects of endogenous prostaglandin E 2 (PGE 2 ) on the production of
interleukin‐6 (IL‐6), macrophage colony stimulating factor (M‐CSF), and vascular endothelial …

[HTML][HTML] Effects of β-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells

M Arai, T Nagasawa, Y Koshihara, S Yamamoto… - … et Biophysica Acta (BBA …, 2003 - Elsevier
In the present study, we demonstrate for the first time that β-adrenergic agonists stimulate
bone-resorbing activity in human osteoclast-like multinucleated cells (MNCs). Osteoclast-like …

[HTML][HTML] Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts

…, M Okada, Y Tanaka, Y Koshihara… - The Journal of …, 1999 - Am Soc Clin Investig
Rheumatoid arthritis (RA) is characterized by a chronic inflammation of the synovial joints
resulting from hyperplasia of synovial fibroblasts and infiltration of lymphocytes, macrophages, …

Mechanism of mustard oil-induced skin inflammation in mice

H Inoue, T Asaka, N Nagata, Y Koshihara - European journal of …, 1997 - Elsevier
We examined the mechanism of the inflammatory response induced by topical application
of mustard oil (0.5–20.0%/20 μl/ear) to the mouse ear compared to that of the response to …