In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage
component and the protection of the cartilage surface from friction-induced wear. Loss-of-…

Bone is a dynamic tissue that is subject to the balanced processes of bone formation and
bone resorption. Imbalance can give rise to skeletal pathologies with increased bone density. …

The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members
of the transforming growth factor β superfamily of signalling proteins (TGFβ-FMs), such as …

Osteoporosis-pseudoglioma syndrome (OPS) is an autosomal recessive disorder characterized
by severe juvenile-onset osteoporosis and congenital or juvenile-onset blindness. The …

Molecular pathogenesis of high‐grade serous ovarian carcinoma (HG‐SOC) is poorly
understood. Recent recognition of HG‐SOC precursor lesions, defined as serous tubal …

Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed
embryo of lotus (Nelumbo nucifera) and exhibit potential anti-cancer activity. Here, we …

We reported that Cullin4B-Ring E3 ligase complex (CRL4B) is physically associated with
Polycomb-repressive complex 2 (PRC2). We showed that CRL4B possesses an intrinsic …

The AT-hook transcription factor HMGA2 is an oncogene involved in the tumorigenesis of
many malignant neoplasms. HMGA2 overexpression is common in both early and late-stage …

We reevaluated a previously reported family with an X-linked mental retardation syndrome
and attempted to identify the underlying genetic defect. Screening of candidate genes in a 10-…