Interaction of spherical particles with cells and within animals has been studied extensively,
but the effects of shape have received little attention. Here we use highly stable, polymer …

The mdx mouse is an X-linked myopathic mutant, an animal model for human Duchenne
muscular dystrophy. In both mouse and man the mutations lie within the dystrophin gene, but …

E type cyclins (E1 and E2) are believed to drive cell entry into the S phase. It is widely assumed
that the two E type cyclins are critically required for proliferation of all cell types. Here, we …

Breast cancer is the most common malignancy among women. Most of these cancers
overexpress cyclin D1, a component of the core cell-cycle machinery. We previously generated …

THE D-type cyclins (Dl, D2 and D3) are critical governors of the cell-cycle clock apparatus
during the Gl phase of the mammalian cell cycle. These three D-type cyclins are expressed in …

D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment
and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse …

Treatments that target immune checkpoints, such as the one mediated by programmed cell
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human cancers …

Background Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven
efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a …

Surfactant has been successfully applied to enhance the dispersion of carbon nanotubes (CNTs)
in polymer and the properties of nanocomposite. CNTs were treated with a nonionic …

A novel route is proposed to produce graphite nanoplatelets (GNPs) and graphene sheets.
The natural graphite flakes were directly exfoliated by ultrasonication in formic acid. A stable …