Objective. Galectin-3 is a multifunctional protein implicated in a variety of biological processes
including fibrosis, angiogenesis, and immune activation, all of which are associated with …

Skin fibrosis in systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose
tissue (dWAT) and reduced levels of circulating adiponectin. Since adiponectin has potent …

Objective: To investigate the clinical significance of monitoring serum adiponectin levels
during intravenous pulse cyclophosphamide (IVCY) in systemic sclerosis (SSc) patients with …

Objective. Visfatin is a member of the adipocytokines with pro-fibrotic, pro-inflammatory and
immunomodulating properties potentially implicated in the pathogenesis of certain fibrotic …

Our latest studies demonstrated the potential role of adipocytokines, including adiponectin,
visfatin, retinol binding protein-4, and apelin, in the pathogenesis of systemic sclerosis (SSc). …

Propranolol hydrochloride is a nonselective β-blocker that is used for the treatment of
hypertension, arrhythmia, and angina pectoris. In Japan, it was recently approved for the treatment …

Objective Angiopoietin-2 (Ang2) regulates the transition between vascular quiescence and
angiogenesis in a context-dependent manner. In systemic sclerosis (SSc), serum Ang2 levels …

Abstract Treatment of perianal and vulvar extramammary Paget disease (EMPD), rare
intraepithelial malignancies, is often challenging because of its potential to spread into the anal …

Background Nivolumab is a monoclonal antibody against programmed death 1 and has
become a standard treatment of advanced melanoma because of its durable response and …

Vitiligo on the forehead (A), neck (B), and dorsal hands (C) after initiation of nivolumab
therapy for melanoma. After treatment with narrow band UVB phototherapy, the lesions on the …