Severe acute respiratory syndrome (SARS) is a zoonotic infectious disease caused by a
novel coronavirus (CoV). The tissue tropism of SARS-CoV includes not only the lung, but also …

Background: Chronic granulomatous disease (CGD) is a rare disorder of phagocytic oxidative
bursts leading to recurrent pyogenic infections. Affected individuals are most prone to …

γδ-T cells represent a small population of immune cells, but play an indispensable role in
host defenses against exogenous pathogens, immune surveillance of endogenous …

Human metapneumovirus (HMPV) is a newly discovered pathogen thought to be associated
with respiratory disease. We report the results of a study of 587 children hospitalized with …

We have recently described the discovery of a novel coronavirus, coronavirus HKU1 (CoV-HKU1),
associated with community-acquired pneumonia. However, the clinical spectrum of …

Lymphopenia and increasing viral load in the first 10 days of severe acute respiratory
syndrome (SARS) suggested immune evasion by SARS-coronavirus (CoV). In this study, we …

Systemic lupus erythematosus is a complex and potentially fatal autoimmune disease,
characterized by autoantibody production and multi-organ damage. By a genome-wide …

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma
diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing …

Interleukin-12 receptor A1 (IL-12RA1) deficiency is the most common form of Mendelian
susceptibility to mycobacterial disease (MSMD). We undertook an international survey of 141 …