A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease

…, T Saeki, H Tsuboi, S Hirata, Y Izumi… - Modern …, 2017 - academic.oup.com
Objective: Although glucocorticoids are effective for patients with IgG4-related disease, the
treatment has not yet been standardized. Therefore, the treatment strategy should be …

[HTML][HTML] Familial Mediterranean fever is no longer a rare disease in Japan

K Migita, Y Izumi, Y Jiuchi, N Iwanaga… - Arthritis research & …, 2016 - Springer
Background The aim of this study was to evaluate the clinical manifestations and prevalence
of familial Mediterranean fever (FMF) in Japanese patients with unexplained fever and …

A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis

T Aramaki, H Ida, Y Izumi, K Fujikawa… - Modern …, 2009 - Taylor & Francis
To elucidate the characterization of peripheral natural killer (NK) cells in patients with
rheumatoid arthritis (RA), we investigated the NK cell activity, the expression of NK cell activating …

Characterization of peripheral natural killer cells in primary Sjögren's syndrome: impaired NK cell activity and low NK cell number

Y Izumi, H Ida, M Huang, N Iwanaga, F Tanaka… - Journal of Laboratory …, 2006 - Elsevier
The aim of this study was to compare the number of peripheral blood natural killer (NK) cells,
NK cell activity, expression of NK cell activating receptors, and serum cytokine levels in …

[HTML][HTML] Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients

…, T Miyamura, S Mori, T Fukui, Y Izumi… - Arthritis Research & …, 2015 - Springer
Introduction Patients with rheumatoid arthritis (RA) treated with abatacept (ABT) are at
increased risk for vaccine-preventable infections. The aim of the present study is to evaluate the …

Clinical outcomes in the first year of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome

…, T Miyashita, N Iwanaga, Y Izumi… - Modern …, 2017 - academic.oup.com
Objective: We investigated clinical outcomes in patients with remitting seronegative
symmetrical synovitis with pitting edema (RS3PE) syndrome. Methods: This is a retrospective …

[HTML][HTML] TNF-α-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts

K Migita, N Iwanaga, Y Izumi, C Kawahara… - BMC research …, 2017 - Springer
Background MicroRNAs (miRNAs) are important regulators of a variety of inflammatory
mediators. The present study was undertaken to elucidate the role of miRNAs in the rheumatoid …

[HTML][HTML] Serum amyloid A induces NLRP-3-mediated IL-1β secretion in neutrophils

K Migita, Y Izumi, Y Jiuchi, H Kozuru, C Kawahara… - PloS one, 2014 - journals.plos.org
Background/Aims Serum amyloid A (SAA) is an acute phase reactant with significant
immunological activities, including effects on cytokine synthesis and neutrophil chemotaxis. …

[HTML][HTML] Rates of serious intracellular infections in autoimmune disease patients receiving initial glucocorticoid therapy

…, T Arai, N Ishizuka, Y Jiuchi, Y Sasaki, Y Izumi… - PLoS …, 2013 - journals.plos.org
Background/Aims The Japanese National Hospital Organization evidence-based medicine (EBM)
Study group for Adverse effects of Corticosteroid therapy (J-NHOSAC) is a Japanese …

Granzyme B leakage‐induced cell death: a new type of activation‐induced natural killer cell death

…, S Yamasaki, M Huang, Y Izumi… - European journal of …, 2003 - Wiley Online Library
Activation‐induced natural killer (NK) cell death is very rapid compared to activation‐induced
T or B cell death. Here we show that NK cell activation is accompanied by the leakage of …