Matrix metalloproteinase (MMP)-7, also known as matrilysin, is a “minimal domain MMP” that
exhibits proteolytic activity against components of the extracellular matrix (ECM). Matrilysin …

To rapidly respond to invading microorganisms, humans call on their innate immune system.
This occurs by microbe‐detecting receptors, such as CD14, that activate immune cells to …

The Monitor of All-sky X-ray Image (MAXI) mission is the first astronomical payload to be
installed on the Japanese Experiment Module — Exposed Facility (JEM-EF or Kibo-EF) on the …

Background/Aims: Kupffer's cells participate in alcohol-induced liver injury, and endotoxemia
is observed in human alcoholics and in a rat model. This study evaluated the effect of …

Considerable evidence for a role of Kupffer cells in alcoholic liver disease has accumulated
and they have recently been shown to be a predominant source of free radicals. Several …

The human intestinal microbiome plays a major role in human health and diseases, including
colorectal cancer. Colorectal carcinogenesis represents a heterogeneous process with a …

… Nakano, Y. Mitsuhashi and all of the members of our laboratory for help with several …
and SA performed the experiments with the technical guidance and expertise of KS, Y.-WZ, …

A new global climate model, MRI-CGCM3, has been developed at the Meteorological
Research Institute (MRI). This model is an overall upgrade of MRI’s former climate model MRI-…

Dectin-2 (gene symbol Clec4n) is a C-type lectin expressed by dendritic cells (DCs) and
macrophages. However, its functional roles and signaling mechanisms remain to be elucidated. …

Dectin-1 is a C-type lectin involved in the recognition of β-glucans found in the cell walls of
fungi. We generated dectin-1-deficient mice to determine the importance of dectin-1 in the …