Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration,
results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the …

Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE)
is implicated in geographic atrophy (GA), an advanced form of age-related macular …

Disruption of the precise balance of positive and negative molecular regulators of blood and
lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors …

Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as
prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of …

Gallic acid [3,4,5-trihydroxybenzoic acid (GA)], a natural phytochemical, is known to have a
variety of cellular functions including beneficial effects on metabolic syndromes. However, …

Neovascularization in response to tissue injury consists of the dual invasion of blood (hemangiogenesis)
and lymphatic (lymphangiogenesis) vessels. We reported recently that 21-nt or …

Background Neuroinflammation is important in the pathogenesis and progression of
Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced …

The discovery of sequence-specific gene silencing by endogenous double-stranded RNAs (dsRNA)
has propelled synthetic short-interfering RNAs (siRNAs) to the forefront of targeted …

OBJECTIVE: To assess the therapeutic potential of rosmarinic acid (RosA) in an inflammatory
autoimmune arthritis model. METHODS: Collagen induced arthritis is established in male …

Gemcitabine has been considered a first-line chemotherapy agent for the treatment of pancreatic
cancer. However, the initial response rate of gemcitabine is low and chemoresistance …