New biomarker evidence of oxidative DNA damage in patients with non‐insulin‐dependent diabetes mellitus
…, H Hiai, H Ochi, P Laippala, V Rantalaiho… - FEBS …, 1997 - Wiley Online Library
Urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) has been reported to serve as a sensitive
biomarker of oxidative DNA damage and also of oxidative stress. We have investigated …
biomarker of oxidative DNA damage and also of oxidative stress. We have investigated …
Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still's disease. An open, randomized, multicenter study
…, R van Vollenhoven, V Rantalaiho… - The Journal of …, 2012 - jrheum.org
Objective. To study the efficacy of anakinra versus disease-modifying antirheumatic drugs (DMARD)
in refractory adult-onset Still’s disease (AOSD). Methods. In a 24-week study, 22 …
in refractory adult-onset Still’s disease (AOSD). Methods. In a 24-week study, 22 …
[HTML][HTML] Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early …
V Rantalaiho, M Korpela, L Laasonen… - Arthritis research & …, 2010 - Springer
Introduction Early treatment of rheumatoid arthritis (RA) has been shown to retard the development
of joint damage for a period of up to 5 years. The aim of this study was to evaluate the …
of joint damage for a period of up to 5 years. The aim of this study was to evaluate the …
Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of …
…, T Lehtimäki, J Laakso, I Ruokonen, V Rantalaiho… - Metabolism, 2003 - Elsevier
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS).
Increased plasma levels of ADMA may indicate endothelial dysfunction and increased …
Increased plasma levels of ADMA may indicate endothelial dysfunction and increased …
The good initial response to therapy with a combination of traditional disease‐modifying antirheumatic drugs is sustained over time: the eleven‐year results of the …
V Rantalaiho, M Korpela, P Hannonen… - Arthritis & …, 2009 - Wiley Online Library
Objective To evaluate the evolution of functional and clinical outcomes over 11 years in
patients with early rheumatoid arthritis (RA) initially treated with a combination of 3 disease‐…
patients with early rheumatoid arthritis (RA) initially treated with a combination of 3 disease‐…
Rates of serious infections and malignancies among patients with rheumatoid arthritis receiving either tumor necrosis factor inhibitor or rituximab therapy
…, P Aronen, H Relas, H Valleala, V Rantalaiho… - The Journal of …, 2015 - jrheum.org
Objective. Because of the role of tumor necrosis factor (TNF) in host defense, it was hypothesized
that its inhibition might lead to an increased risk of malignancies and infections. The …
that its inhibition might lead to an increased risk of malignancies and infections. The …
Targeted treatment with a combination of traditional DMARDs produces excellent clinical and radiographic long-term outcomes in early rheumatoid arthritis regardless …
V Rantalaiho, H Kautiainen, M Korpela… - Annals of the …, 2014 - ard.bmj.com
Objective To study whether adding initial infliximab to remission-targeted initial combination-DMARD
treatment improves the long-term outcomes in patients with early rheumatoid …
treatment improves the long-term outcomes in patients with early rheumatoid …
Increasing incidence and shifting profile of idiopathic inflammatory rheumatic diseases in adults during this millennium
P Muilu, V Rantalaiho, H Kautiainen, LJ Virta… - Clinical …, 2019 - Springer
To explore the trends in the incidence of idiopathic inflammatory rheumatic diseases (IIRDs)
after the turn of the millennium. From a nationwide register maintained by the Social …
after the turn of the millennium. From a nationwide register maintained by the Social …
Decline in work disability caused by early rheumatoid arthritis: results from a nationwide Finnish register, 2000–8
VM Rantalaiho, H Kautiainen, S Järvenpää… - Annals of the …, 2013 - ard.bmj.com
Objectives To study whether the work disability (WD) rates in early rheumatoid arthritis (RA)
have changed in Finland, where the treatment of RA has long been active but has intensified …
have changed in Finland, where the treatment of RA has long been active but has intensified …
Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NIDDM
XH Huang, V Rantalaiho, O Wirta, A Pasternack… - Human genetics, 1998 - Springer
The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D)
polymorphism has been shown to be associated with cardiovascular and renal …
polymorphism has been shown to be associated with cardiovascular and renal …