Cardiac troponin‐I on diagnosis predicts early death and refractoriness in acquired thrombotic thrombocytopenic purpura. Experience of the French Thrombotic …

…, D Alain, F Olivier, FB Véronique… - … of Thrombosis and …, 2015 - Wiley Online Library
Background Cardiac involvement is a major cause of mortality in patients with thrombotic
thrombocytopenic purpura (TTP). However, diagnosis remains underestimated and delayed, …

A prospective international study on adherence to treatment in 305 patients with flaring SLE: assessment by drug levels and self‐administered questionnaires

…, F Houssiau, P Izmirly, VL Guern… - Clinical …, 2019 - Wiley Online Library
Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine ( HCQ ), a
major medication in systemic lupus erythematosus, has a long half‐life and can be …

A paradigm of diagnostic criteria for polyarteritis nodosa: analysis of a series of 949 patients with vasculitides

…, JD Zucker, A Bar‐Hen, VL Guern… - Arthritis & …, 2008 - Wiley Online Library
Objective To establish a set of clinical and paraclinical criteria potentially useful as a
diagnostic screening tool for polyarteritis nodosa (PAN). Methods The abilities of individual …

Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study)

…, P Eloy, D Belhadi, J Chezel, VL Guern… - …, 2022 - academic.oup.com
Objective The detection of somatic mutations among the genes of myeloid cells in
asymptomatic patients—defining clonal haematopoiesis of indeterminate potential (CHIP)—is …

Clinical presentation, course, and prognosis of patients with mixed connective tissue disease: A multicenter retrospective cohort

…, B Dunogue, P Cohen, VL Guern… - Journal of internal …, 2023 - Wiley Online Library
Objectives The objective of this study is to better characterize the features and outcomes of
a large population of patients with mixed connective tissue disease (MCTD). Methods We …

Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome

J Keraen, E Blanc, FL Besson, V Leguern… - Arthritis & …, 2019 - Wiley Online Library
Objective The usefulness of positron emission tomography–computed tomography ( PET ‐
CT ) with 18 F‐labeled fluorodeoxyglucose ( 18 F‐ FDG ) for the diagnosis of lymphoma in …

Hydroxychloroquine: a multifaceted treatment in lupus

…, B Dunogue, N Morel, V Le Guern… - La Presse Médicale, 2014 - Elsevier
The efficacy of antimalarials, especially hydroxychloroquine (HCQ), in preventing systemic
lupus erythematosus (SLE) flares is well demonstrated. However, many studies show that the …

Adherence to treatment in systemic lupus erythematosus patients

…, J Pouchot, G Guettrot-Imbert, V Le Guern… - Best practice & research …, 2013 - Elsevier
Adherence is defined as “the extent to which a person's behaviour coincides with medical or
health advice.” Poor adherence to therapeutic regimens is a common and expensive …

Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study)

…, O Aumaître, C Francès, V Le Guern… - Annals of the …, 2013 - ard.bmj.com
Introduction Hydroxychloroquine (HCQ) is an important medication for treating systemic lupus
erythematosus (SLE). Its blood concentration ([HCQ]) varies widely between patients and …

A critical review of the effects of hydroxychloroquine and chloroquine on the eye

…, G Leroux, N Morel, M Jallouli, V Le Guern… - Clinical reviews in …, 2015 - Springer
Hydroxychloroquine (HCQ) and chloroquine have been used for more than 50 years to treat
systemic lupus erythematosus (SLE) and other rheumatic diseases. In general, these drugs …