User profiles for ULRICH SPECKS

Ulrich Specks

Professor of Medicine, Mayo Clinic
Verified email at mayo.edu
Cited by 30968

ANCA-associated vasculitis

…, PA Merkel, COS Savage, U Specks… - Nature reviews Disease …, 2020 - nature.com
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group
of disorders involving severe, systemic, small-vessel vasculitis and are characterized by …

Antineutrophil cytoplasmic antibodies

GS Hoffman, U Specks - Bulletin on the Rheumatic Diseases, 1998 - search.proquest.com
Antineutrophil cytoplasmic antibodies (ANCAs) have been an increasingly prominent topic
in the literature on vasculitis for over 15 years. Although there is much to learn about the …

[HTML][HTML] Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis

…, A Radice, JA Savige, RA Sinico, U Specks… - Nature Reviews …, 2017 - nature.com
Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for
the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with …

[HTML][HTML] Rituximab versus cyclophosphamide for ANCA-associated vasculitis

…, C Stegeman, SR Ytterberg, U Specks - … England Journal of …, 2010 - Mass Medical Soc
Background Cyclophosphamide and glucocorticoids have been the cornerstone of
remission-induction therapy for severe antineutrophil cytoplasmic antibody (ANCA)−associated …

[HTML][HTML] Efficacy of remission-induction regimens for ANCA-associated vasculitis

U Specks, PA Merkel, P Seo, R Spiera… - … England Journal of …, 2013 - Mass Medical Soc
Background The 18-month efficacy of a single course of rituximab as compared with conventional
immunosuppression with cyclophosphamide followed by azathioprine in patients with …

[HTML][HTML] Mepolizumab or placebo for eosinophilic granulomatosis with polyangiitis

…, PA Merkel, F Moosig, U Specks… - … England Journal of …, 2017 - Mass Medical Soc
Background Eosinophilic granulomatosis with polyangiitis is an eosinophilic vasculitis.
Mepolizumab, an anti–interleukin-5 monoclonal antibody, reduces blood eosinophil counts and …

Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener granulomatosis

B Nolle, U Specks, J Lüdemann… - Annals of Internal …, 1989 - acpjournals.org
Study Objective: To determine disease specificity and sensitivity of anticytoplasmic
autoantibodies (ACPA) for Wegener granulomatosis, as well as their value as a marker of disease …

[HTML][HTML] Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis

…, WF Clark, C Pagnoux, U Specks… - … England Journal of …, 2020 - Mass Medical Soc
Background More effective and safer treatments are needed for antineutrophil cytoplasmic
antibody (ANCA)–associated vasculitis. Methods We conducted a randomized trial with a 2-by…

Induction of remission by B lymphocyte depletion in eleven patients with refractory antineutrophil cytoplasmic antibody–associated vasculitis

…, ME Wylam, JH Stone, U Specks - Arthritis & Rheumatism …, 2005 - Wiley Online Library
Objective To assess the clinical effects of rituximab therapy in patients with antineutrophil
cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods The study group …

A disease‐specific activity index for Wegener's granulomatosis: modification of the Birmingham Vasculitis Activity Score

…, ML Uhlfelder, DB Hellmann, U Specks… - Arthritis & …, 2001 - Wiley Online Library
Objective To refine and validate the Birmingham Vasculitis Activity Score (BVAS) as a
disease‐specific activity index for Wegener's granulomatosis (WG). Methods Sixteen members of …