We examined the impact of pretreatment neutrophil count on survival in patients with advanced
non-small-cell lung cancer (NSCLC). A total of 388 chemo-naïve patients with stage IIIB …

Sphingomyelin (SM) synthase has been assumed to be involved in both cell death and survival
by regulating pro-apoptotic mediator ceramide and pro-survival mediator diacylglycerol. …

We investigated the possibility of the proapoptotic lipid ceramide as an indicator of chemoresistance
in leukemia. Doxorubicin (DOX) increased the ceramide level and apoptosis in drug-…

Objective. Methotrexate-associated lymphoproliferative disorders (MTX-LPD) often regress
spontaneously during MTX withdrawal, but the prognostic factors remain unclear. The aim of …

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a devastating complication
of hematopoietic stem cell transplantation. TA-TMA likely represents the final stage of …

Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an elusive …

Sphingolipid ceramide has emerged as a lipid messenger of cell functions including
differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and …

Graft-versus-host disease-free, relapse-free survival (GRFS) is a useful composite end point
that measures survival without relapse or significant morbidity after allogeneic …

Regardless of the existence of ceramide-related molecules, such as sphingomyelin (SM),
neutral sphingomyelinase (nSMase), and SM synthase, in the nucleus, the regulation of …

This study reveals the major role of gains, amplifications, and mutations of EPOR and JAK2
in the pathogenesis of pure erythroleukemia. Their frequent response to ruxolitinib in patient-…