Acute kidney injury: Epidemiology, outcomes, complications, and therapeutic strategies
…, S Kobayashi, T Yano, K Tatsuta, T Mima… - Seminars in …, 2018 - Wiley Online Library
Acute kidney injury (AKI) is one of the most common serious complications for all hospital
admissions, with its incidence increasing among hospitalized patients, particularly those in the …
admissions, with its incidence increasing among hospitalized patients, particularly those in the …
Clinical value of blocking IL-6 receptor
T Mima, N Nishimoto - Current opinion in rheumatology, 2009 - journals.lww.com
… Toru Mima, as a medical advisor, received the consultant fee from Chugai
Pharmaceutical Co., Ltd. Norihiro Nishimoto, as a medical advisor, received the consultant …
Pharmaceutical Co., Ltd. Norihiro Nishimoto, as a medical advisor, received the consultant …
Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti–IL-6 receptor antibody …
N Nishimoto, K Terao, T Mima… - Blood, The Journal …, 2008 - ashpublications.org
Interleukin-6 (IL-6) plays pathologic roles in immune-inflammatory diseases such as rheumatoid
arthritis (RA) and Castleman disease. By inhibiting IL-6 receptors (IL-6Rs), tocilizumab (…
arthritis (RA) and Castleman disease. By inhibiting IL-6 receptors (IL-6Rs), tocilizumab (…
Interleukin 6 plays a key role in the development of antigen-induced arthritis
S Ohshima, Y Saeki, T Mima, M Sasai… - Proceedings of the …, 1998 - National Acad Sciences
To investigate the direct role of interleukin (IL) 6 in the development of rheumatoid arthritis,
IL-6-deficient (IL-6 −/−) mice were backcrossed for eight generations into C57BL/6 mice, a …
IL-6-deficient (IL-6 −/−) mice were backcrossed for eight generations into C57BL/6 mice, a …
Successful treatment of a patient with takayasu arteritis using a humanized anti–interleukin‐6 receptor antibody
…, H Nakahara, N Yoshio‐Hoshino, T Mima - Arthritis & …, 2008 - Wiley Online Library
Takayasu arteritis (TA) is a chronic inflammatory disease that involves the aorta and its major
branches. Since overproduction of interleukin‐6 (IL‐6) seems to play a pathogenic role in …
branches. Since overproduction of interleukin‐6 (IL‐6) seems to play a pathogenic role in …
Delayed onset and reduced severity of collagen‐induced arthritis in interleukin‐6–deficient mice
…, S Ohshima, K Nishioka, T Mima… - … : Official Journal of …, 1999 - Wiley Online Library
Objective To investigate the roles of interleukin‐6 (IL‐6) in the pathogenesis of rheumatoid
arthritis (RA) by studying its effect on murine collagen‐induced arthritis (CIA). Methods IL‐6–…
arthritis (RA) by studying its effect on murine collagen‐induced arthritis (CIA). Methods IL‐6–…
Enhanced local production of osteopontin in rheumatoid joints.
S Ohshima, N Yamaguchi, K Nishioka, T Mima… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: To investigate the involvement of osteopontin (OPN) in the pathogenesis of
rheumatoid arthritis (RA), localization and production of OPN were examined in patients with RA…
rheumatoid arthritis (RA), localization and production of OPN were examined in patients with RA…
RANKL‐induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis
…, E Kudo‐Tanaka, T Ishii, T Mima… - Journal of Bone and …, 2006 - academic.oup.com
We showed that CD9, a member of tetraspanin superfamily proteins, is expressed in a
specific membrane microdomain, called “lipid raft,” and is crucial for cell fusion during …
specific membrane microdomain, called “lipid raft,” and is crucial for cell fusion during …
Isolation and expression profiling of genes upregulated in the peripheral blood cells of systemic lupus erythematosus patients
…, A Tanigawa, S Ohshima, H Fujiwara, T Mima… - DNA …, 2005 - academic.oup.com
We have identified the genes whose expressions are augmented in the blood cells of the
patients with systemic lupus erythematosus (SLE) using the ‘stepwise subtraction’ technique …
patients with systemic lupus erythematosus (SLE) using the ‘stepwise subtraction’ technique …
Fibroblast growth factor 23 production in bone is directly regulated by 1α, 25-dihydroxyvitamin D, but not PTH
…, H Orita, Y Maeda, M Ooura, T Mima… - American Journal …, 2010 - journals.physiology.org
Fibroblast growth factor 23 (FGF23), which is primarily produced by osteocytes in bone,
regulates renal phosphate excretion and 1α,25-dihydroxyvitamin D [1,25(OH) 2 D 3 ] metabolism…
regulates renal phosphate excretion and 1α,25-dihydroxyvitamin D [1,25(OH) 2 D 3 ] metabolism…