Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome

K Takenaka, T Ai, W Shimizu, A Kobori, T Ninomiya… - Circulation, 2003 - Am Heart Assoc
Background— Experimental studies suggest that the interval between peak and end of T wave
(Tpe) in transmural ECGs reflects transmural dispersion of repolarization (TDR), which is …

High Risk for Bradyarrhythmic Complications in Patients With Brugada Syndrome Caused by SCN5AGene Mutations

…, S Ohno, K Takenaka, A Kobori, T Ninomiya… - Journal of the American …, 2005 - jacc.org
Objectives : We carried out a complete screening of the SCN5Agene in 38 Japanese patients
with Brugada syndrome to investigate the genotype-phenotype relationship. Background : …

Characterization and subcellular localization of KCNQ1 with a heterozygous mutation in the C terminus

…, H Yoshida, Y Yumoto, A Kobori, T Ninomiya… - Journal of molecular and …, 2001 - Elsevier
Numerous mutations in KCNQ1, a gene encoding the α -subunit of cardiac delayed rectifier
potassium channels, have been found in long QT syndrome (LQTS). Among them, several …

Additional gene variants reduce effectiveness of beta‐blockers in the LQT1 form of long QT syndrome

…, S Ohno, K Takenaka, T Ninomiya… - Journal of …, 2004 - Wiley Online Library
Introduction: Beta‐blockers are widely used to prevent the lethal cardiac events associated
with the long QT syndrome (LQTS), especially in KCNQ1‐related LQTS (LQT1) patients. …

α1-Adrenoceptor-Mediated Breakdown of Phosphatidylinositol 4,5-Bisphosphate Inhibits Pinacidil-Activated ATP-Sensitive K+ Currents in Rat Ventricular Myocytes

…, TY Nakamura, LH Xie, H Otani, T Ninomiya… - Circulation …, 2002 - Am Heart Assoc
Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) stimulates ATP-sensitive K + (K ATP ) channel
activity. Because phospholipase C (PLC) hydrolyzes membrane-bound PIP 2 , which in …

Successful radiofrequency current catheter ablation of accessory atrioventricular pathway in Ebstein's anomaly using electroanatomic mapping

…, M Watanuki, N Amaya, T Ninomiya… - Pacing and clinical …, 2002 - Wiley Online Library
AI, T., et al.: Successful Radiofrequency Current Catheter Ablation of Accessory Atrioventricular
Path‐way in Ebstein's Anomaly using Electroanatomic Mapping. Ebstein's anomaly is …

Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6. 2)

T Ninomiya, M Takano, T Haruna… - Journal of …, 2003 - journals.lww.com
This study investigated the mechanism by which verapamil, which blocks 10R1, l-type Ca 2+
channel and the HERG channel, blocks ATP-sensitive K+(K ATP) channels. In whole cell …

Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates KATP channels in guinea-pig ventricular myocytes

…, Y Kono, H Yoshida, H Otani, T Kubota, T Ninomiya… - Pflügers Archiv, 2000 - Springer
Sarcolemmal adenosine 5′-triphosphate-sensitive K + channels (K ATP ) are dramatically
up-regulated by a membrane phospholipid, phosphatidyl-inositol-4,5-bisphosphate (PIP 2 ). …

Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock

Y Yumoto, M Horie, T Kubota, T Ninomiya… - Journal of …, 2004 - journals.lww.com
Whole-cell patch-clamp techniques were employed to examine the effects of bepridil, a Ca 2+
channel blocker with Vaughan Williams class III action, on a slow component of cardiac …

Insulinotropic action of glutamate is dependent on the inhibition of ATP-sensitive potassium channel activities in MIN 6 β cells

H Katsuta, S Ozawa, T Ninomiya, T Shimoyama… - Biochemical and …, 2003 - Elsevier
To investigate the cellular mechanism of insulinotropic effect of glutamate in pancreatic β
cells, we utilized patch-clamp technique to monitor directly the activities of ATP-sensitive …