The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM
T Koga, K Fujikawa, Y Horai, A Okada… - …, 2012 - academic.oup.com
Objective. Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a
major poor prognostic factor in patients with DM. We investigated the association of anti-…
major poor prognostic factor in patients with DM. We investigated the association of anti-…
[HTML][HTML] TNF-α-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts
…, C Kawahara, K Kumagai, T Nakamura, T Koga… - BMC research …, 2017 - Springer
Background MicroRNAs (miRNAs) are important regulators of a variety of inflammatory
mediators. The present study was undertaken to elucidate the role of miRNAs in the rheumatoid …
mediators. The present study was undertaken to elucidate the role of miRNAs in the rheumatoid …
Lupus nephritis IgG induction of calcium/calmodulin‐dependent protein kinase IV expression in podocytes and alteration of their function
…, Y Nakashima, T Suzuki, Y Horai, T Koga… - Arthritis & …, 2016 - Wiley Online Library
Objective Kidney podocytes and their slit diaphragms prevent urinary protein loss. T cells
from patients with systemic lupus erythematosus display increased expression of calcium/…
from patients with systemic lupus erythematosus display increased expression of calcium/…
[HTML][HTML] Hydroxychloroquine inhibits IL-1β production from amyloid-stimulated human neutrophils
…, T Urano, H Kozuru, H Yatsuhashi, T Koga… - Arthritis Research & …, 2019 - Springer
Background Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic
diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is …
diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is …
Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy
…, A Igarashi, R Sogame, T Hashimoto, T Koga… - Annals of the …, 2012 - ard.bmj.com
Objectives Myositis-specific autoantibodies (MSAs) are useful tools for identifying clinically
homogeneous subsets and predicting prognosis of patients with idiopathic inflammatory …
homogeneous subsets and predicting prognosis of patients with idiopathic inflammatory …
[HTML][HTML] CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance
T Koga, CM Hedrich, M Mizui… - The Journal of …, 2014 - Am Soc Clin Investig
Tissue inflammation in several autoimmune diseases, including SLE and MS, has been linked
to an imbalance of IL-17–producing Th (Th17) cells and Tregs; however, the factors that …
to an imbalance of IL-17–producing Th (Th17) cells and Tregs; however, the factors that …
[HTML][HTML] M1 and M2 monocytes in rheumatoid arthritis: a contribution of imbalance of M1/M2 monocytes to osteoclastogenesis
…, M Umeda, A Nishino, Y Horai, Y Hirai, T Koga… - Frontiers in …, 2018 - frontiersin.org
Objectives We investigated the relationships among M1 monocytes, M2 monocytes, osteoclast
(OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (…
(OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (…
[PDF][PDF] Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells
T Koga, S Yamasaki, K Migita, J Kita… - Clinical and …, 2011 - clinexprheumatol.org
Objective Zc3h12a is an RNA binding protein with a CCCH-type finger motif and is known to
regulate mRNA metabolism. Previous reports suggest that Zc3h12a acts as a negative …
regulate mRNA metabolism. Previous reports suggest that Zc3h12a acts as a negative …
The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease …
…, M Tamai, H Nakamura, A Okada, T Koga… - …, 2011 - academic.oup.com
Objective. We evaluated the significance of the power Doppler ultrasonography (PDUS)
score by comparing it with serum biomarkers and clinical disease activity. Methods. We …
score by comparing it with serum biomarkers and clinical disease activity. Methods. We …
CD4+ CD25highCD127low/-Treg cell frequency from peripheral blood correlates with disease activity in patients with rheumatoid arthritis
SY Kawashiri, A Kawakami, A Okada, T Koga… - The Journal of …, 2011 - jrheum.org
Objective. To investigate whether the frequency of peripheral blood (PB) regulatory T cells (Treg)
correlates with the clinical disease activity of rheumatoid arthritis (RA). Methods. PB …
correlates with the clinical disease activity of rheumatoid arthritis (RA). Methods. PB …