Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

…, T Baradet, D Locke, Q Wu, TP Reilly, P Phillips… - Nature medicine, 2020 - nature.com
Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated with worse
prognosis in advanced cancers. Here, using a large-scale retrospective analysis, we show …

Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice

C Ju, TP Reilly, M Bourdi, MF Radonovich… - Chemical research in …, 2002 - ACS Publications
Hepatic injury induced by various toxic agents, including acetaminophen (APAP), has been
attributed, in part, to the production of proinflammatory cytokines and other mediators by …

Protection against acetaminophen-induced liver injury and lethality by interleukin 10: role of inducible nitric oxide synthase

M Bourdi, Y Masubuchi, TP Reilly, HR Amouzadeh… - Hepatology, 2002 - journals.lww.com
Mechanistic study of idiosyncratic drug-induced hepatitis (DIH) continues to be a challenging
problem because of the lack of animal models. The inability to produce this type of …

[HTML][HTML] Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma

…, JE Schoenhals, AP Cadena, TP Reilly… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Despite some successes with checkpoint inhibitors for treating cancer, most
patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor stroma …

Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease

Y Masubuchi, M Bourdi, TP Reilly, MLM Graf… - Biochemical and …, 2003 - Elsevier
Recent experimental data suggest that the idiosyncratic nature of drug-induced liver disease
(DILD) may be due in part to a deficiency of one or more hepatoprotective factors. In this …

A protective role for cyclooxygenase-2 in drug-induced liver injury in mice

TP Reilly, JN Brady, MR Marchick… - Chemical research in …, 2001 - ACS Publications
Despite the utility of cyclooxygenase (COX) inhibition as an antiinflammatory strategy,
prostaglandin (PG) products of COX-1 and -2 provide important regulatory functions in some …

[HTML][HTML] A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions

TP Reilly, LH Lash, MA Doll, DW Hein… - Journal of Investigative …, 2000 - Elsevier
Cutaneous reactions are the most common manifestation of delayed-type hypersensitivity
caused by sulfamethoxazole and dapsone. In light of the recognized metabolic and …

[PDF][PDF] Role of neutrophils in a mouse model of halothane‐induced liver injury

Q You, L Cheng, TP Reilly, D Wegmann, C Ju - Hepatology, 2006 - Wiley Online Library
Drug‐induced liver injury (DILI) is a major safety concern in drug development. Its prediction
and prevention have been hindered by limited knowledge of the underlying mechanisms, in …

Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone

TP Reilly, FH Bellevue III, PM Woster… - Biochemical …, 1998 - Elsevier
The differential incidence of adverse drug reactions (ADR) between trimethoprim-sulfamethoxazole
and dapsone might be explained, in part, by differences in the inherent toxicity of the …

Triple therapy with MerTK and PD1 inhibition plus radiotherapy promotes abscopal antitumor immune responses

…, M Quigley, H Menon, C Gao, T Spires, TP Reilly… - Clinical Cancer …, 2019 - AACR
Purpose: Radiotherapy (RT) traditionally has been used for local tumor control in the
treatment of cancer. The recent discovery that radiotherapy can have anticancer effects on the …