Methotrexate withdrawal in patients with rheumatoid arthritis who achieve low disease activity with tofacitinib modified-release 11 mg once daily plus methotrexate …

…, M Korkosz, A Diehl, JL Rivas, T Lukic… - The Lancet …, 2019 - thelancet.com
Background Tofacitinib is an oral Janus kinase (JAK) inhibitor used for the treatment of
rheumatoid arthritis. We assessed the efficacy and safety of tofacitinib after methotrexate …

[HTML][HTML] Tofacitinib versus biologic treatments in moderate-to-severe rheumatoid arthritis patients who have had an inadequate response to nonbiologic DMARDs …

E Bergrath, RA Gerber, D Gruben, T Lukic… - International Journal of …, 2017 - hindawi.com
Objective. To compare the efficacy and tolerability of tofacitinib, an oral Janus kinase inhibitor
for the treatment of rheumatoid arthritis (RA), as monotherapy and combined with disease-…

Efficacy of tofacitinib in reducing pain in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis

…, K De Vlam, IB McInnes, PJ Mease, P Baer, T Lukic… - RMD open, 2020 - rmdopen.bmj.com
Objective To describe the efficacy of tofacitinib in reducing pain in patients with rheumatoid
arthritis (RA), psoriatic arthritis (PsA) or ankylosing spondylitis (AS) in a post-hoc analysis of …

[HTML][HTML] Meaningful changes in what matters to individuals with vitiligo: content validity and meaningful change thresholds of the vitiligo area scoring index (VASI)

…, KW Wyrwich, C Carmichael, LS Deal, T Lukic… - Dermatology and …, 2022 - Springer
Introduction This study explored patients’ and dermatologists’ priority outcomes for treatment
to address, clinical outcome assessments (COA) for use in vitiligo clinical trials, and …

[HTML][HTML] Efficacy and safety of tofacitinib in patients with rheumatoid arthritis by previous treatment: post hoc analysis of phase II/III trials

J Tesser, A Gül, E Olech, K Oelke, T Lukic… - Arthritis Research & …, 2023 - Springer
Background This study sought to evaluate the efficacy and safety of tofacitinib in patients with
rheumatoid arthritis with distinct treatment histories. Methods Pooled phase II/III trial data …

Modified-versus immediate-release tofacitinib in Japanese rheumatoid arthritis patients: a randomized, phase III, non-inferiority study

Y Tanaka, N Sugiyama, S Toyoizumi, T Lukic… - …, 2019 - academic.oup.com
Objective Tofacitinib is an oral Janus kinase inhibitor for treatment of RA. We compared
tofacitinib modified-release (MR) 11 mg once daily (QD) with tofacitinib immediate-release (IR) 5 …

Efficacy and safety of tofacitinib modified-release 11 mg once daily plus methotrexate in adult patients with rheumatoid arthritis: 24-week open-label phase results from …

…, J Pope, B Haraoui, E Mysler, A Diehl, T Lukic… - RMD open, 2021 - rmdopen.bmj.com
Objectives To report the efficacy, safety and patient-reported outcome measures (PROs) of
tofacitinib modified-release 11 mg once daily plus methotrexate in patients with rheumatoid …

Disodium ascorbyl phytostanyl phosphate reduces plasma cholesterol concentrations and atherosclerotic lesion formation in apolipoprotein E-deficient mice

T Lukic, KM Wasan, D Zamfir, MH Moghadasian… - Metabolism, 2003 - Elsevier
Disodium ascorbyl phytostanyl phosphate (FM-VP4) consists of ascorbic acid covalently
bound to phytostanols by a phosphodiester linkage and is derived as the disodium salt. The …

[HTML][HTML] Real-world evidence to contextualize clinical trial results and inform regulatory decisions: tofacitinib modified-release once-daily vs immediate-release twice …

…, A Madsen, TW Smith, D Gruben, R Zhang, T Lukic… - Advances in …, 2021 - Springer
Introduction Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid
arthritis (RA). To provide additional clinical evidence in regulatory submissions for a modified-…

Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol™) tall oil-derived phytosterols in apo …

PH Pritchard, M Li, C Zamfir, T Lukic, E Novak… - … drugs and therapy, 2003 - Springer
The cholesterol-lowering and anti-atherogenic effects of non-hydrogenated (FCP-3P1
containing 69% β-sitosterol, 16% sitostanol, and 13% campesterol) and hydrogenated (FCP-3P2 …