Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease

K Yoshizaki, T Matsuda, N Nishimoto, T Kuritani… - 1989 - ashpublications.org
Castleman's disease is a syndrome consisting of giant lymph node hyperplasia with plasma
cell infiltration, fever, anemia, hypergammaglobulinemia, and an increase in the plasma …

Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I …

N Nishimoto, K Yoshizaki, K Maeda, T Kuritani… - The Journal of …, 2003 - jrheum.org
OBJECTIVE: To evaluate the safety and pharmacokinetics of multiple infusions of a humanized
anti-interleukin-6 (IL-6) receptor antibody, MRA, in patients with rheumatoid arthritis (RA). …

T cell-replacing factor-(TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF.

A Muraguchi, T Kishimoto, Y Miki, T Kuritani… - … (Baltimore, Md.: 1950 …, 1981 - journals.aai.org
IgG-secretion was induced in a human B blastoid cell line, CESS, by the addition of partially
purified T cell-derived helper factor(s) (TRF), which had been obtained from PHA-stimulated …

Interleukin 6 and expression of its receptor on epidermal keratinocytes

…, K Matsumoto, H Tagoh, T Taga, Y Deguchi, T Kuritani… - Cytokine, 1990 - Elsevier
Interleukin 6 (IL 6) was detected in the culture supernatants of human epidermal keratinocytes
and its production was enhanced by stimulation with cytokines. Production of IL 6 in …

Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy/tropical spastic paraparesis

…, K Machigashira, H Tagoh, A Ogata, T Kuritani… - Journal of the …, 1990 - Elsevier
A significant elevation of interleukin-6 (IL-6) level was observed both in serum (mean 0.455
± 0.251) and in cerebrospinal fluid (CSF) (mean 0.043 ± 0.016) obtained from 13 patients …

In Vitro Immune Response of Human Peripheral Lymphocytes: I. The Mechanism(s) Involved in T Cell Helper Functions in the Pokeweed Mitogen-Induced …

T Hirano, T Kuritani, T Kishimoto… - The Journal of …, 1977 - journals.aai.org
Human peripheral lymphocytes (PBL) upon stimulation with PWM proliferate and differentiate
to IgM- and IgG-producing cells. The PWM-induced Ig production in B cells was dependent …

A new highly sensitive immunoassay for cytokines by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA)

A Ogata, H Tagoh, T Lee, T Kuritani, Y Takahara… - Journal of …, 1992 - Elsevier
Non-isotopic immunoassays for human tumor necrosis factor α (TNFα) and human
interleukin-6 (IL-6) were established by employing the dissociation-enhanced lanthanide …

Human b-cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed …

T Kuritani, MD Cooper - The Journal of experimental medicine, 1982 - rupress.org
Monoclonal antibodies were used to examine the immunoglobulin isotypes expressed by B
lymphocyte precursors of IgM, IgG, IgA, and IgA2 plasma cells. Plasma-cell differentiation …

Induction of IgG production in human B lymphoblastoid cell lines with normal human T cells

T Kishimoto, T Hirano, T Kuritani, Y Yamamura… - Nature, 1978 - nature.com
THYMUS-DERIVED (T) lymphocytes play a critical part in the induction of B lymphocytes to
antibody production 1 , especially for conversion of IgM to IgG response 2 . In humans, the …

Psychological state is related to the remission of the Boolean-based definition of patient global assessment in patients with rheumatoid arthritis

…, N Murata, N Takai, K Higashi, T Kuritani… - Modern …, 2015 - academic.oup.com
Objectives. To evaluate whether the psychological state is related to the Boolean-based
definition of patient global assessment (PGA) remission in patients with rheumatoid arthritis (RA)…