The role of inflammation in epilepsy

A Vezzani, J French, T Bartfai, TZ Baram - Nature reviews neurology, 2011 - nature.com
Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring
predisposition to generate seizures. Despite progress in pharmacological and surgical …

Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo

…, XJ Xu, Z Wiesenfeld-Hallin, T Hökfelt, T Bartfai… - Nature …, 1998 - nature.com
Peptide nucleic acids (PNAs) form stable and tight complexes with complementary DNA and/or
RNA and would be promising antisense reagents if their cellular delivery could be …

Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section

XJ Xu, JX Hao, S Andell-Jonsson, V Poli, T Bartfai… - Cytokine, 1997 - Elsevier
The cutaneous nociceptive response threshold to mechanical and thermal stimulation, the
development of hyperalgesia and plasma extravasation after subcutaneous injection of …

Interleukin‐1β contributes to the generation of experimental febrile seizures

…, A Vezzani, M Behrens, T Bartfai… - Annals of Neurology …, 2005 - Wiley Online Library
Fever can provoke “febrile” seizures (FS). Because complex FS may promote development
of temporal lobe epilepsy, understanding their mechanisms is clinically important. Using an …

[HTML][HTML] A blood based 12-miRNA signature of Alzheimer disease patients

…, F Paul, C Stähler, CJG Lang, B Meder, T Bartfai… - Genome biology, 2013 - Springer
Background Alzheimer disease (AD) is the most common form of dementia but the identification
of reliable, early and non-invasive biomarkers remains a major challenge. We present a …

[PDF][PDF] Cytokines and fever

B Conti, I Tabarean, C Andrei, T Bartfai - Front Biosci, 2004 - researchgate.net
… are the findings that cell penetrating ceramide analogs such as C2 ceramide can in vivo
mediate fever like rise in temperature when applied intracerebroventricularly (Bartfai et al., …

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

…, M Maroso, S Balosso, MA Sanchez, T Bartfai - Brain, behavior, and …, 2011 - Elsevier
Increasing evidence supports the involvement of immune and inflammatory processes in
the etiopathogenesis of seizures. In particular, activation of innate immune mechanisms and …

Transgenic mice with a reduced core body temperature have an increased life span

…, S Henriksen, EP Zorrilla, L De Lecea, T Bartfai - Science, 2006 - science.org
Reduction of core body temperature has been proposed to contribute to the increased life
span and the antiaging effects conferred by calorie restriction (CR). Validation of this …

VE-cadherin-derived cell-penetrating peptide, pVEC, with carrier functions

A Elmquist, M Lindgren, T Bartfai, Ü Langel - Experimental cell research, 2001 - Elsevier
Cell-penetrating peptides, CPPs, have been shown to translocate into living cells by a
receptor-independent mechanism and to carry macromolecules over the plasma membrane. This …

Neuropeptides: opportunities for drug discovery

T Hökfelt, T Bartfai, F Bloom - The Lancet Neurology, 2003 - thelancet.com
The role of peptides as signalling molecules in the nervous system has been studied for more
than 30 years. Neuropeptides and their G-protein-coupled receptors are widely distributed …