Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors
Y Sasakawa, Y Naoe, T Noto, T Inoue… - Biochemical …, 2003 - Elsevier
It has been recently demonstrated that histone deacetylase inhibitors inhibit angiogenesis,
but their mechanism of action has not been characterized well. In this study, we examined the …
but their mechanism of action has not been characterized well. In this study, we examined the …
[HTML][HTML] Different pathophysiology and outcomes of heart failure with preserved ejection fraction stratified by K-means clustering
D Harada, H Asanoi, T Noto… - Frontiers in cardiovascular …, 2020 - frontiersin.org
Background: Stratified medicine may enable the development of effective treatments for
particular groups of patients with heart failure with preserved ejection fraction (HFpEF); however, …
particular groups of patients with heart failure with preserved ejection fraction (HFpEF); however, …
Different pathophysiology underlying animal models of fibromyalgia and neuropathic pain: comparison of reserpine-induced myalgia and chronic constriction injury …
Y Nagakura, M Takahashi, T Noto, T Sekizawa… - Behavioural brain …, 2012 - Elsevier
The reserpine-induced myalgia (RIM) rat manifests fibromyalgia-like chronic pain symptoms.
The present study explored the pathophysiology underlying the pain symptoms in the RIM …
The present study explored the pathophysiology underlying the pain symptoms in the RIM …
Prevention of renal interstitial fibrosis via histone deacetylase inhibition in rats with unilateral ureteral obstruction
F Kinugasa, T Noto, H Matsuoka, Y Urano, Y Sudo… - Transplant …, 2010 - Elsevier
Acute rejection following renal transplantation has become manageable with the introduction
of calcineurin inhibitors, FK506 and cyclosporine A. However, chronic allograft dysfunction …
of calcineurin inhibitors, FK506 and cyclosporine A. However, chronic allograft dysfunction …
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing …
A Takeuchi-Yorimoto, T Noto, A Yamada… - Toxicology and applied …, 2013 - Elsevier
Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis,
lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of …
lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of …
Mechanisms of HDAC inhibitor-induced thrombocytopenia
H Matsuoka, A Unami, T Fujimura, T Noto… - European journal of …, 2007 - Elsevier
Histone deacetylase inhibitors (HDAC inhibitors) are an emerging class of anticancer agents.
To elucidate the mechanism of HDAC inhibitor-induced thrombocytopenia, we focused on …
To elucidate the mechanism of HDAC inhibitor-induced thrombocytopenia, we focused on …
The antiglaucoma agent and EP2 receptor agonist omidenepag does not affect eyelash growth in mice
Y Esaki, O Katsuta, H Kamio, T Noto… - Journal of Ocular …, 2020 - liebertpub.com
Purpose: The present study investigated the effects of the antiglaucoma agent and selective
E2 receptor agonist omidenepag isopropyl (OMDI) on eyelash growth in comparison with a …
E2 receptor agonist omidenepag isopropyl (OMDI) on eyelash growth in comparison with a …
MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease
…, Y Yamaura, M Kanki, T Ide, A Nakata, T Noto… - Toxicology letters, 2016 - Elsevier
Evidence indicates that hepatic fibrosis is the initial lesion of cirrhosis or hepatocellular
carcinoma in diseases such as nonalcoholic steatohepatitis (NASH). To induce NASH, we fed …
carcinoma in diseases such as nonalcoholic steatohepatitis (NASH). To induce NASH, we fed …
[HTML][HTML] The impact of right ventricular dysfunction on the effectiveness of beta-blockers in heart failure with preserved ejection fraction
D Harada, H Asanoi, T Noto, J Takagawa - Journal of Cardiology, 2020 - Elsevier
Background Whether beta-blockers improve the clinical outcomes for heart failure with
preserved ejection fraction (HFpEF) characterized by variable cardiac pathophysiology remains …
preserved ejection fraction (HFpEF) characterized by variable cardiac pathophysiology remains …
Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats
Y Furuichi, T Noto, JY Li, T Oku, M Ishiye, A Moriguchi… - Brain research, 2004 - Elsevier
While the immunosuppressant tacrolimus (FK506) is known to be neuroprotective following
cerebral ischemia, the mechanisms underlying its neuroprotective properties are not fully …
cerebral ischemia, the mechanisms underlying its neuroprotective properties are not fully …