Medication‐related osteonecrosis of the jaw (MRONJ) is an adverse event that may inhibit
the treatment of primary disease and remarkably influence the patient's quality of life. The …

Tumor associated macrophages ( TAM s) are the most abundant cancer stromal cells educated
by tumor microenvironment to acquire trophic functions facilitating angiogenesis, matrix …

Claudins are transmembrane proteins that seal tight junctions, bind with peripheral protein
zonula occludens (ZO)-1, and are known to play an important role in several normal tissues …

Objectives. Necrotizing fasciitis of the head and neck is an uncommon, potentially fatal soft
tissue infection characterized by extensive necrosis and gas formation in the subcutaneous …

Tumor cells are thought to evade immune surveillance through interaction with immune cells.
Much recent attention has focused on the modification of immune responses as a basis for …

… Soutome, Sakiko DDS, PhD a ; Yanamoto, Souichi DDS, PhD b,* ; Funahara, Madoka DH,
PhD b ; Hasegawa, Takumi DDS, PhD c ; Komori, Takahide DDS, PhD c ; Yamada, Shin-ichi …

The purpose of this study is to evaluate local levels of interleukin-1β (IL-1β), -4 (IL-4), -6 (IL-6),
and tumour necrosis factor-α (TNF-α), in a model of murine osteomyelitis due to …

Objective Osteoradionecrosis of the jaw is a serious late adverse event in patients with
head and neck cancer undergoing radiotherapy. The aim of this study is to investigate the …

Recently, an Er:YAG laser has attracted attention because of the possibility of cutting hard
tissues with extremely small thermal effects. In this article, we report 8 cases (13 teeth) of …

OBJECTIVE: Programmed death-1 (PD-1) mediates a negative signal and introduces
tolerance for lymphocytes. Dysfunction of the PD-1 pathway is thought to result in autoimmune …