Programmed death-1 (PD-1)–PD-1 ligand (PD-L) signaling system is involved in the
functional impairment of T cells such as in chronic viral infection or tumor immune evasion. We …

We investigated the possibility of the proapoptotic lipid ceramide as an indicator of chemoresistance
in leukemia. Doxorubicin (DOX) increased the ceramide level and apoptosis in drug-…

The role of "sphingolipid rheostat" by ceramide and sphingosine 1-phosphate (S1P) in the
regulation of autophagy remains unclear. In human leukemia HL-60 cells, amino acid …

We sought to clarify the role of high-dose chemotherapy followed by autologous
hematopoietic stem cell transplantation (auto-HSCT) and allogeneic hematopoietic stem cell …

Objective. Methotrexate-associated lymphoproliferative disorders (MTX-LPD) often regress
spontaneously during MTX withdrawal, but the prognostic factors remain unclear. The aim of …

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a devastating complication
of hematopoietic stem cell transplantation. TA-TMA likely represents the final stage of …

Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an elusive …

Knowing the impact of chronic graft-versus-host disease (GVHD) on quality of life (QoL) after
allogeneic hematopoietic stem cell transplantation (allo-HCT) by GVHD type and severity is …

Castleman’s disease (CD), also known as giant or angiofollicular lymph node hyperplasia,
is a rare polyclonal lymphoproliferative disorder named after the pathologist who first …

We herein describe an unusual case of multicentric Castleman’s disease accompanied by
thrombocytopenia, ascites, renal failure and myelofibrosis in a Japanese woman. The patient …