Natural RNA circles function as efficient microRNA sponges

TB Hansen, TI Jensen, BH Clausen, JB Bramsen… - Nature, 2013 - nature.com
MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression that
act by direct base pairing to target sites within untranslated regions of messenger RNAs 1 . …

[PDF][PDF] The impact of Covid-19 on higher education around the world

G Marinoni, H Van't Land, T Jensen - IAU global survey report, 2020 - uniss.it
In December 2019, a viral outbreak of pneumonia of unknown origin occurred in Wuhan,
China. On 9 January 2020, the World Health Organization (WHO) officially announced the …

Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma

TO Jensen, H Schmidt, HJ Møller, F Donskov… - Cancer, 2012 - Wiley Online Library
BACKGROUND: Tumor cell and host immune cell interaction plays a key role in carcinogenesis.
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in …

[PDF][PDF] Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma

TO Jensen, H Schmidt, HJ Moller, M Hoyer… - J Clin oncol, 2009 - academia.edu
Purpose To evaluate the prognostic role of soluble CD163 (sCD163) in serum and
macrophage infiltration in primary melanomas from patients with American Joint Committee on …

Another phocine distemper outbreak in Europe

T Jensen, M Van de Bildt, HH Dietz, TH Andersen… - Science, 2002 - science.org
The seal population of Northern Europe was able to recover from the 1988 phocine distemper
epidemic that killed about 18,000 seals. However, starting at the beginning of May 2002, …

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

…, N Borcherding, V Garin, M White, C Schutt, TI Jensen… - Science, 2023 - science.org
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor
responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that …

Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population

S Rasmussen, TH Jensen, SL Henriksen… - Scandinavian journal …, 2015 - Taylor & Francis
Introduction. Gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable
bowel syndrome (IBS) are common functional gastrointestinal conditions with significant …

Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi

TI Jensen, NS Mikkelsen, Z Gao, J Foßelteder… - Genome …, 2021 - genome.cshlp.org
Targeted transcriptional activation or interference can be induced with the CRISPR-Cas9
system (CRISPRa/CRISPRi) using nuclease-deactivated Cas9 fused to transcriptional effector …

[HTML][HTML] Proliferation indices of phosphohistone H3 and Ki67: strong prognostic markers in a consecutive cohort with stage I/II melanoma

PS Nielsen, R Riber-Hansen, TO Jensen, H Schmidt… - Modern Pathology, 2013 - Elsevier
Cellular proliferation is correlated with the progression of melanoma. Accordingly, the
proliferation index of H&E-stained thin melanomas was recently included in the staging system of …

[HTML][HTML] Argonaute-associated short introns are a novel class of gene regulators

TB Hansen, MT Venø, TI Jensen, A Schaefer… - Nature …, 2016 - nature.com
MicroRNAs (miRNAs) are short (∼22 nucleotides) regulators of gene expression acting by
direct base pairing to 3′-UTR target sites in messenger RNAs. Mature miRNAs are …