User profiles for TIMOTHY R.D.J. RADSTAKE
Timothy RadstakeHead Early Immunology Discovery Research, Abbvie Verified email at abbvie.com Cited by 29756 |
Cytokine expression in keratoconus and its corneal microenvironment: a systematic review
…, JJW Kuiper, R Gans, S Imhof, TRDJ Radstake… - The ocular …, 2015 - Elsevier
Keratoconus (KC) is a progressive corneal ecstasia characterized by thinning and weakening
of the cornea that leads to a cone-like appearance, scarring, and decreased vision. …
of the cornea that leads to a cone-like appearance, scarring, and decreased vision. …
[HTML][HTML] Morphea and eosinophilic fasciitis: an update
…, MMB Seyger, RM Thurlings, TRDJ Radstake… - American journal of …, 2017 - Springer
Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic
skin diseases. The spectrum ranges from relatively mild phenotypes, which generally …
skin diseases. The spectrum ranges from relatively mild phenotypes, which generally …
The role of genetics and epigenetics in the pathogenesis of systemic sclerosis
JCA Broen, TRDJ Radstake, M Rossato - Nature Reviews …, 2014 - nature.com
Systemic sclerosis (SSc) is a complex autoimmune disease of unclear aetiology. A multitude
of genetic studies, ranging from candidate-gene studies to genome-wide association studies…
of genetic studies, ranging from candidate-gene studies to genome-wide association studies…
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
…, L Padyukov, MD Posthumus, TRDJ Radstake… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …
[HTML][HTML] Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
…, I Devesa, MF Roelofs, TRDJ Radstake… - The Journal of …, 2008 - Am Soc Clin Investig
TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial
or host-derived ligands found in arthritic joints. Here, we show that TLR2 and TLR4, but …
or host-derived ligands found in arthritic joints. Here, we show that TLR2 and TLR4, but …
Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis
TRDJ Radstake, M Svenson, AM Eijsbouts… - Annals of the …, 2009 - ard.bmj.com
Background: Tumour necrosis factor α (TNFα) neutralising antibody constructs are
increasingly being used to treat rheumatoid arthritis (RA). Objective: To determine potential …
increasingly being used to treat rheumatoid arthritis (RA). Objective: To determine potential …
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and
internal organs that leads to profound disability and premature death. To identify new SSc …
internal organs that leads to profound disability and premature death. To identify new SSc …
[HTML][HTML] Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
…, R Lafyatis, TRDJ Radstake - New England journal …, 2014 - Mass Medical Soc
Background Plasmacytoid dendritic cells have been implicated in the pathogenesis of
systemic sclerosis through mechanisms beyond the previously suggested production of type I …
systemic sclerosis through mechanisms beyond the previously suggested production of type I …
Expression of Toll‐like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin‐12 and interleukin‐18 via interferon‐γ
TRDJ Radstake, MF Roelofs… - Arthritis & …, 2004 - Wiley Online Library
Objective To study the expression of Toll‐like receptor 2 (TLR‐2) and TLR‐4 and its association
with proinflammatory cytokines in synovial tissue from patients with rheumatoid arthritis (…
with proinflammatory cytokines in synovial tissue from patients with rheumatoid arthritis (…
[HTML][HTML] Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci
…, B Cukrowska, MJH Coenen, TRDJ Radstake… - PLoS …, 2011 - journals.plos.org
Epidemiology and candidate gene studies indicate a shared genetic basis for celiac
disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been …
disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been …