[HTML][HTML] Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised …

B Williams, TM MacDonald, S Morant, DJ Webb… - The Lancet, 2015 - thelancet.com
Background Optimal drug treatment for patients with resistant hypertension is undefined. We
aimed to test the hypotheses that resistant hypertension is most often caused by excessive …

Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease

L Wei, TM MacDonald, BR Walker - Annals of internal medicine, 2004 - acpjournals.org
Background: Glucocorticoids have adverse systemic effects, including obesity, hypertension,
and hyperglycemia, that may predispose to cardiovascular disease. The effect of …

Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus

…, DIR Boyle, AD McMahon, SA Greene, TM MacDonald… - The Lancet, 1997 - thelancet.com
Background Intensive insulin treatment effectively delays the onset and slows the progression
of microvascular complications in insulin-dependent diabetes mellitus (IDDM). Variable …

Adherence to prescribed oral hypoglycaemic medication in a population of patients with Type 2 diabetes: a retrospective cohort study

PT Donnan, TM MacDonald, AD Morris - Diabetic Medicine, 2002 - Wiley Online Library
Aims To evaluate the patterns and predictors of adherence in all patients with Type 2 diabetes
in the community receiving treatment with a single oral hypoglycaemic drug. In particular, …

Socio‐economic status, obesity and prevalence of Type 1 and Type 2 diabetes mellitus

…, RW Newton, DA Ruta, TM MacDonald… - Diabetic …, 2000 - Wiley Online Library
Aims The influence of socio‐economic status on the prevalence of Type 1 and Type 2 diabetes
mellitus, and on obesity, was explored using routinely collected healthcare data for the …

Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study

N Tzemos, PO Lim, TM MacDonald - Circulation, 2001 - Am Heart Assoc
Background Vascular endothelial dysfunction may predict future atherosclerosis. Hence, an
antihypertensive agent that reverses endothelial dysfunction and lowers blood pressure …

Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy

…, SR Bonellie, RT Jung, TM MacDonald… - The Journal of …, 2010 - academic.oup.com
Context: For patients on T 4 replacement, the dose is guided by serum TSH concentrations,
but some patients request higher doses due to adverse symptoms. Objective: The aim of the …

[HTML][HTML] Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective …

…, AD Struthers, CC Lang, TM MacDonald - The Lancet, 2022 - thelancet.com
Background Studies have suggested that evening dosing with antihypertensive therapy
might have better outcomes than morning dosing. The Treatment in Morning versus Evening (…

Review of aldosterone-and angiotensin II-induced target organ damage and prevention

AD Struthers, TM MacDonald - Cardiovascular research, 2004 - academic.oup.com
Aldosterone is well recognized as a cause of sodium reabsorption, water retention, and
potassium and magnesium loss; however, it also produces a variety of other actions that lead to …

Frequency of blood glucose monitoring in relation to glycaemic control: observational study with diabetes database

JMM Evans, RW Newton, DA Ruta, TM MacDonald… - bmj, 1999 - bmj.com
Objectives: To investigate patterns of self monitoring of blood glucose concentration in diabetic
patients who use insulin and to determine whether frequency of self monitoring is related …