Background Interleukin 6 is involved in the pathogenesis of rheumatoid arthritis via its broad
effects on immune and inflammatory responses. Our aim was to assess the therapeutic …

Objective To examine the efficacy and safety of the humanized anti–interleukin‐6 receptor
antibody tocilizumab combined with conventional disease‐modifying antirheumatic drugs (…

Background: The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of
IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis. Objective: To evaluate through …

Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an
excellent target for clinical immunosuppression. We report the development of a specific, …

Psoriasis is a hyperproliferative and inflammatory skin disorder of unknown aetiology. A fusion
protein composed of human interleukin-2 and fragments of diphtheria toxin (DAB 389 IL-2)…

This study sought to determine 1) the incidence and costs of new onset diabetes mellitus (NODM)
associated with maintenance immunosuppression regimens following renal …

Objective To develop a scoring system for quantifying osteoarthritic changes of the knee as
identified by magnetic resonance (MR) imaging, and to determine its inter- and intra-…

Objective Chemokines such as CCL2/monocyte chemotactic protein 1 (MCP‐1) play a key
role in leukocyte migration and are potential targets in the treatment of chronic inflammatory …

Background For patients with newly diagnosed rheumatoid arthritis, treatment aim is early,
rapid, and sustained remission. We compared the efficacy and safety of strategies initiating …

Objective Significant variation in interleukin‐1β (IL‐1β) protein secretion between subjects
has been observed when using a lipopolysaccharide (LPS)/ATP–mediated ex vivo blood …