Background Ixekizumab, a high-affinity interleukin-17A (IL-17A) monoclonal antibody, has
previously shown efficacy in radiographic axial spondyloarthritis (also known as ankylosing …

Objective: To evaluate autoimmune disease progression in asymptomatic and pauci-symptomatic
mothers of children with neonatal lupus (NL). Methods: Clinical information on mothers …

… Izmirly MD , Tania L. Rivera MD , Jill P. Buyon MD … Boutjdir, we confirmed and
extended these results by showing that affinity-purified anti–52-kD Ro antibodies induce AV …

BACKGROUND: Systemic lupus erythematosus (SLE) is associated with premature
atherosclerosis but the mechanisms underlying this association are not understood. The role of …

Objective. The type I interferon (IFN) pathway is activated in many patients with systemic
lupus erythematosus (SLE), and high serum levels of IFN are associated with anti-SSA/Ro …

Background : Cardiac manifestations of neonatal lupus (cardiac NL) include congenital heart
block and cardiomyopathy. Several candidate biomarkers were evaluated in cases at risk …

Objective. To evaluate responses to mycophenolate mofetil (MMF) and intravenous
cyclophosphamide (CYC) in lupus nephritis in a multiethnic population. Methods. This was a …

Objective. To study the membrane expression of endothelial protein C receptor (mEPCR) in
the renal microvasculature in lupus nephritis (LN) as a potential marker of injury and/or …

Genetics, environment, and gender contribute to the pathogenesis of systemic lupus erythematosus
(SLE). As in other autoimmune diseases, females are more often afflicted than males…

A 76-year-old woman who had been diagnosed with rheumatoid arthritis (RA) sought further
treatment at Beth Israel Medical Center. The patient had suffered from pain over her arms …