User profiles for TAKAHIKO NAKAGAWA
Takahiko NakagawaShiga Univ of Medical Science Verified email at belle.shiga-med.ac.jp Cited by 32497 |
A causal role for uric acid in fructose-induced metabolic syndrome
T Nakagawa, H Hu, S Zharikov… - American Journal …, 2006 - journals.physiology.org
The worldwide epidemic of metabolic syndrome correlates with an elevation in serum uric
acid as well as a marked increase in total fructose intake (in the form of table sugar and high-…
acid as well as a marked increase in total fructose intake (in the form of table sugar and high-…
[HTML][HTML] Hyperuricemia induces endothelial dysfunction
UM Khosla, S Zharikov, JL Finch, T Nakagawa… - Kidney international, 2005 - Elsevier
Hyperuricemia induces endothelial dysfunction. Background Hyperuricemia has been linked
to cardiovascular and renal diseases, possibly through the generation of reactive oxygen …
to cardiovascular and renal diseases, possibly through the generation of reactive oxygen …
A role for uric acid in the progression of renal disease
DH Kang, T Nakagawa, L Feng… - Journal of the …, 2002 - journals.lww.com
ABSTRACT. Hyperuricemia is associated with renal disease, but it is usually considered a
marker of renal dysfunction rather than a risk factor for progression. Recent studies have …
marker of renal dysfunction rather than a risk factor for progression. Recent studies have …
[HTML][HTML] Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
RJ Johnson, MS Segal, Y Sautin, T Nakagawa… - The American journal of …, 2007 - Elsevier
Currently, we are experiencing an epidemic of cardiorenal disease characterized by
increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney …
increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney …
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
…, S Watanabe, T Nakagawa… - American Journal …, 2002 - journals.physiology.org
Hyperuricemia is associated with hypertension and vascular disease, but whether this represents
a causal relationship or an epiphenomenon remains unknown. We recently reported a …
a causal relationship or an epiphenomenon remains unknown. We recently reported a …
Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
…, S Watanabe, JH Li, DH Kang, P Li, T Nakagawa… - …, 2003 - Am Heart Assoc
Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC)
proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory …
proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory …
Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
YY Sautin, T Nakagawa, S Zharikov… - American Journal of …, 2007 - journals.physiology.org
Uric acid is considered a major antioxidant in human blood that may protect against aging
and oxidative stress. Despite its proposed protective properties, elevated levels of uric acid …
and oxidative stress. Despite its proposed protective properties, elevated levels of uric acid …
Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
S Watanabe, DH Kang, L Feng, T Nakagawa… - …, 2002 - Am Heart Assoc
Humans have elevated serum uric acid as a result of a mutation in the urate oxidase (uricase)
gene that occurred during the Miocene. We hypothesize that the mutation provided a …
gene that occurred during the Miocene. We hypothesize that the mutation provided a …
Sugar, uric acid, and the etiology of diabetes and obesity
The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup
has increased dramatically in the last hundred years and correlates closely with the rise in …
has increased dramatically in the last hundred years and correlates closely with the rise in …
Fructose and sugar: A major mediator of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome;
its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result …
its rising prevalence parallels the rise in obesity and diabetes. Historically thought to result …