K/BxN T cell receptor transgenic mice are a model of inflammatory arthritis, similar to rheumatoid
arthritis. Disease in these animals is focused specifically on the joints but stems from …

Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized
by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex
pathogenesis in which genetic, hormonal and environmental factors have a role. Rare …

Objective To assess the safety, mechanism of action, and preliminary efficacy of rituximab
followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods In a …

Systemic lupus erythematosus (SLE), a complex polygenic autoimmune disease, is associated
with increased complement activation. Variants of genes encoding complement regulator …

In systemic lupus erythematosus, the renal deposition of complement-containing immune
complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation of the …

Rationale: Severe pulmonary arterial hypertension (SPH) is a frequently lethal condition
characterized by pulmonary vascular remodeling and right heart strain or failure. SPH is also …

Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disorder
characterized by the loss of tolerance to self-antigens and dysregulated interferon responses. …

The major murine systemic lupus erythematosus (SLE) susceptibility locus, Sle1, corresponds
to three loci independently affecting loss of tolerance to chromatin in the NZM2410 mouse. …

We previously reported that the G allele of rs3853839 at 3′untranslated region (UTR) of
Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased …