Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display
variable sensitivity to therapeutics and may play different roles in progression. We previously …

Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease
for which there is no targeted therapy 1 , 2 , 3 . BET bromodomain inhibitors, which have …

Breast cancer comprises a heterogeneous group of malignancies derived from the ductal
epithelium. The microenvironment of these cancers is now recognized as a critical participant …

It is unknown why only a minority of circulating tumor cells trapped in lung capillaries form
metastases and involvement of immune cells remains uncertain. A novel model has been …

To investigate immune escape during breast tumor progression, we analyzed the composition
of leukocytes in normal breast tissues, ductal carcinoma in situ (DCIS), and invasive …

Synthesis and identification of novel phenylalkyl isoselenocyanates (ISCs), isosteric selenium
analogues of naturally occurring phenylalkyl isothiocyanates (ITCs), as effective cytotoxic …

OBJECTIVE: To assess the therapeutic potential of rosmarinic acid (RosA) in an inflammatory
autoimmune arthritis model. METHODS: Collagen induced arthritis is established in male …

Purpose: Melanoma is the most invasive and deadly form of skin cancer. Few agents are
available for treating advanced disease to enable long-term patient survival, which is driving …

The frequency and proliferative activity of tissue-specific stem and progenitor cells are
suggested to correlate with cancer risk. In this study, we investigated the association between …

Expression of macrophage inhibitory cytokine-1 (MIC-1), a member of the transforming
growth factor-β family, normally increases during inflammation or organ injury. MIC-1 is also …