Objective CONCERTO was a randomised, double-blind, parallel-armed study of methotrexate
(MTX) in combination with adalimumab to assess whether an increasing trend of efficacy …

Objective. To evaluate the efficacy and safety of ixekizumab (IXE), an interleukin 17A
antagonist, in patients with psoriatic arthritis (PsA) after 52 weeks in a phase III study. Methods. …

Objective To evaluate the presence of spinal inflammation with and without sacroiliac (SI)
joint inflammation on magnetic resonance imaging (MRI) in patients with active …

Objective. Chronic pain and progressive loss of physical function with AS may adversely
affect health-related quality of life (HRQoL). The objective of this study was to assess the 5-year …

Objective The aim was to assess the safety and efficacy of up to 156 weeks of ixekizumab (an
IL-17A antagonist) treatment in PsA patients. Methods In a phase III study, patients naïve to …

Objective To identify factors predicting response (2‐hour headache pain freedom or most
bothersome symptom freedom) to lasmiditan based on individual patient characteristics, …

Introduction Migraine is associated with substantial functional impairment and affects many
aspects of daily life. Methods Using data from SAMURAI and SPARTAN (double-blind, …

Objective To conduct subset analyses of SPIRIT-P2 ( NCT02349295 ) to investigate the
efficacy and safety of ixekizumab versus placebo in three subgroups of patients with active …

… Doppler activity as core lesions of ultrasound-detected enthesitis, but this work is not fully
validated [32]. GRAPPA is also attempting to develop an imaging index for enthesitis [33, 34]. …

… expect when patients adhere is important. Patients are advised to take their medication as
directed; therefore, it is important to assess what happens if a medication is taken as directed …