Mast cells play an essential role during development of inflammation after chemical and
immunological insults and have been implicated in tissue fibrosis and angiogenesis. The exact …

PURPOSE: Platelet-derived growth factor (PDGF) and its receptors could contribute to the
development of proliferative retinal membranes, because PDGF is angiogenic and is both …

Objective. To test the hypothesis that local proliferation contributes significantly to the hyperplasia
of rheumatoid synovium. Methods. Immunohistologic and chemical staining was used …

PURPOSE: An intertwined cascading network of cytokines is believed to direct the development
of endotoxin-induced uveitis (EIU). This study investigated mRNA levels of interleukin (IL…

Immunologic pathways involved in sarcoidosis pathogenesis are largely unknown. We
hypothesized that patients with sarcoidosis have characteristic mRNA profiles. Microarray …

Objective Blau syndrome is a rare, autosomal‐dominant, autoinflammatory disorder characterized
by granulomatous arthritis, uveitis, and dermatitis. Genetics studies have shown that …

Background Peripheral blood is an accessible and informative source of transcriptomal
information for many human disease and pharmacogenomic studies. While there can be …

We previously reported that mast cells (MCs) serve as a source of basic fibroblast growth
factor (bFGF), a potent angiogenic and mitogenic polypeptide, suggesting that bFGF may …

PURPOSE: Integrins are cell surface proteins that participate in interactions between cells
and with extracellular matrix. Binding of integrins to their ligands influences cell activities …

purpose. Cell-adhesion molecules are critical elements in intravascular rolling and sticking
of leukocytes during acute inflammation. In this process, selectins are thought to be involved …