User profiles for Sonya Abraham
Sonya AbrahamImperial College Verified email at ic.ac.uk Cited by 2421 |
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
SM Abraham, T Lawrence, A Kleiman… - The Journal of …, 2006 - rupress.org
Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory
diseases, inhibit the expression of many inflammatory mediators. They can also induce the …
diseases, inhibit the expression of many inflammatory mediators. They can also induce the …
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
M Lasa, SM Abraham, C Boucheron… - … and cellular biology, 2002 - Am Soc Microbiol
The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti-inflammatory …
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti-inflammatory …
Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised …
Background Chlamydia is the most common sexually transmitted bacterial infection
worldwide. National screening programmes and antibiotic treatment have failed to decrease …
worldwide. National screening programmes and antibiotic treatment have failed to decrease …
Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway
S Alzabin, SM Abraham, TE Taher… - Annals of the …, 2012 - ard.bmj.com
Objectives To establish if changes in Th1/Th17 cell populations previously reported in
experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour …
experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour …
Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis
E Pathan, S Abraham, E Van Rossen… - Annals of the …, 2013 - ard.bmj.com
Objectives To evaluate the efficacy and safety of an oral phosphodiesterase 4 inhibitor,
apremilast, in treatment of ankylosing spondylitis (AS) by monitoring symptoms and signs in a …
apremilast, in treatment of ankylosing spondylitis (AS) by monitoring symptoms and signs in a …
[HTML][HTML] Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo …
M Al-Laith, M Jasenecova, S Abraham, A Bosworth… - Trials, 2019 - Springer
Trial design We present a study protocol for a multi-centre, randomised, double-blind,
parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and …
parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and …
The evidence for microbiome manipulation in inflammatory arthritis
H Jethwa, S Abraham - Rheumatology, 2017 - academic.oup.com
The human body consists of millions of commensal bacteria (the microbiome), with the
intestinal tract being the most prevalent site of colonization. This colonization process begins at …
intestinal tract being the most prevalent site of colonization. This colonization process begins at …
Covid-19 vaccine trials: Ethnic diversity and immunogenicity
H Jethwa, R Wong, S Abraham - Vaccine, 2021 - Elsevier
In recent years it has become increasingly recognised that immunogenicity of vaccines can
vary significantly between individuals, with age, comorbidities and medication use being …
vary significantly between individuals, with age, comorbidities and medication use being …
Telemedicine in rheumatology at the advent of the COVID-19 pandemic
…, DD Wu, H Jethwa, S Abraham - HSS Journal®, 2020 - journals.sagepub.com
In late 2019, a hematologist from the University of North Carolina received a phone call from
space—it was a request to evaluate an astronaut on the International Space Station who …
space—it was a request to evaluate an astronaut on the International Space Station who …
Quantitative power Doppler ultrasound measures of peripheral joint synovitis in poor prognosis early rheumatoid arthritis predict radiographic progression
Objective. To assess the value of quantitative vascular imaging by power Doppler US (PDUS)
as a tool that can be used to stratify patient risk of joint damage in early seropositive RA …
as a tool that can be used to stratify patient risk of joint damage in early seropositive RA …