Predicting renal outcome in antineutrophil cytoplasmic antibody (ANCA)–associated
glomerulonephritis (GN) remains a major challenge. We aimed to identify reliable predictors of end-…

Th17 cells are most abundant in the gut, where their presence depends on the intestinal
microbiota. Here, we examined whether intestinal Th17 cells contribute to extra-intestinal Th17 …

Innate lymphoid cells (ILCs) have an important role in the immune system's response to
different forms of infectious and noninfectious pathologies. In particular, IL-5–and IL-13–…

Chemokines and chemokine receptors are implicated in regulatory T cell (Treg) trafficking to
sites of inflammation and suppression of excessive immune responses in inflammatory and …

A pathogenic role for Th17 cells in inflammatory renal disease is well established. The
mechanisms underlying their counter-regulation are, however, largely unknown. Recently, Th17 …

The IL-17 cytokine family and the cognate receptors thereof have a unique role in organ-specific
autoimmunity. Most studies have focused on the founding member of the IL-17 family, IL-…

Objective COVID‐19 is a novel infectious disease with a broad spectrum of clinical severity.
Patients with systemic vasculitis have an increased risk of serious infections and may be at …

Persistent inflammation is a hallmark of many human diseases, including anti-neutrophil
cytoplasmic antibody-associated vasculitis (AAV) and atherosclerosis. Here, we describe a …

Background Prospective randomized trials investigating treatments and outcomes in anti–glomerular
basement membrane (anti-GBM) disease are sparse, and validated tools to aid …

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial
growth factor and is used for treating multiple cancer types. As a known and frequent …