Tendon progenitor cells in injured tendons have strong chondrogenic potential: the CD105-negative subpopulation induces chondrogenic degeneration

S Asai, S Otsuru, ME Candela, L Cantley, K Uchibe… - Stem …, 2014 - academic.oup.com
To study the cellular mechanism of the tendon repair process, we used a mouse Achilles
tendon injury model to focus on the cells recruited to the injured site. The cells isolated from …

IL-1β irreversibly inhibits tenogenic differentiation and alters metabolism in injured tendon-derived progenitor cells in vitro

K Zhang, S Asai, B Yu, M Enomoto-Iwamoto - Biochemical and biophysical …, 2015 - Elsevier
Tendon injuries are common, and the damaged tendon often turns into scar tissue and never
completely regains the original biomechanical properties. Previous studies have reported …

Depression, physical function, and disease activity associated with frailty in patients with rheumatoid arthritis

…, Y Waguri-Nagaya, N Takahashi, S Asai… - Modern …, 2021 - academic.oup.com
Objectives To investigate the clinical and psychosocial backgrounds of frailty in rheumatoid
arthritis (RA) patients. Methods Patients with RA between 40 and 79 years of age who visited …

Alexithymia, depression, inflammation, and pain in patients with rheumatoid arthritis

…, M Hanabayashi, S Hirabara, S Asai… - Arthritis care & …, 2014 - Wiley Online Library
Objective We previously reported that depression and inflammation have independent effects
on pain severity in patients with rheumatoid arthritis (RA). Alexithymia is a personality trait …

Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles …

K Zhang, S Asai, MW Hast, M Liu, Y Usami, M Iwamoto… - Matrix Biology, 2016 - Elsevier
Ectopic tendon mineralization can develop following tendon rupture or trauma surgery. The
pathogenesis of ectopic tendon mineralization and its clinical impact have not been fully …

[HTML][HTML] Predictors for clinical effectiveness of baricitinib in rheumatoid arthritis patients in routine clinical practice: data from a Japanese multicenter registry

N Takahashi, S Asai, T Kobayakawa, A Kaneko… - Scientific Reports, 2020 - nature.com
This study aimed to evaluate the short-term effectiveness and safety profiles of baricitinib
and explore factors associated with improved short-term effectiveness in patients with …

[HTML][HTML] Clinical efficacy of abatacept, tocilizumab, and etanercept in Japanese rheumatoid arthritis patients with inadequate response to anti-TNF monoclonal …

…, M Hayashi, K Funahashi, M Hanabayashi, S Asai… - Clinical …, 2014 - Springer
The aim of this study was to compare the efficacy and retention rates of three biologics (abatacept,
tocilizumab, and etanercept) after switching from first-course anti-TNF monoclonal …

Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis

S Asai, K Nagai, N Takahashi… - International Journal …, 2019 - Wiley Online Library
Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis -
Asai - 2019 - International Journal of Rheumatic Diseases - Wiley Online Library …

Importance of methotrexate therapy concomitant with tocilizumab treatment in achieving better clinical outcomes for rheumatoid arthritis patients with high disease …

…, M Hanabayashi, S Asai, S Hirabara, N Asai… - …, 2015 - academic.oup.com
Objective. The purpose of this study was to identify the effects of concomitant use of MTX and
baseline characteristics for remission in the treatment of RA with tocilizumab (TCZ) in daily …

Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: a 14-year trend analysis (2004–2017)

S Asai, N Takahashi, N Asai, S Yamashita… - Modern …, 2020 - academic.oup.com
Objectives: To examine time trends in the characteristics of patients with rheumatoid arthritis
(RA) undergoing primary total joint replacement (TJR). Methods: Biologics were approved in …