We have investigated the effect of interleukin 6 (IL-6) on the growth of vascular smooth muscle
cells (VSMC) isolated from rat aortas. Murine recombinant IL-6 significantly increased the …

Factors controlling the proliferation of vascular smooth muscle cells (SMC) are thought to be
key elements in the progression of atherosclerosis. We have previously shown that …

OBJECTIVE To examine the effects of a novel immunosuppressant, FTY720, on hematolymphoid
cells and the clinical course of MRL-lpr/lpr (MRL/lpr) mice genetically predisposed to …

Leukocyte adhesion to vascular endothelium is a crucial step in the early stages of atherosclerosis,
which may be mediated by the interaction of adhesion molecules expressed on the …

Background Adhesion of monocytes to the endothelium is an initial step in the early stages
of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-…

We have investigated the effect of interleukin-1 (IL-1) on the growth of vascular smooth muscle
cells (VSMC) isolated from rat aortae. Murine recombinant IL-la increased tritiated leucine …

Although the accumulation of monocyte-derived foam cells in the subendothelium is a key
step in early atherogenesis, the mechanism responsible for monocyte adhesion to and …

Monocyte chemoattractant protein-1 (MCP-1, or monocyte chemotactic and activating factor)
plays important roles in the recruitment of monocytes and thus in the development of …

Objective: The adhesive interaction of monocytes and endothelial cells has been implicated
as a regulatory signal in the cell activation that is involved in the pathogenesis of …

Streptococcal immunopotentiator OK-432 (NSCB116209) augmented the natural killer (NK)
cell activity of peritoneal exudate cells (PEC) in inbred C57BLl6 mice given ip injections of …