Microbial nucleic acid recognition serves as the major stimulus to an antiviral response,
implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the …

Background To our knowledge, the characteristics and burden of childhood arthritis have
never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional study…

Kawasaki shock syndrome (KSS) is a rare manifestation of Kawasaki disease (KD) characterized
by systolic hypotension or clinical signs of poor perfusion. The objectives of the study …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are rare systemic
diseases that usually occur in adulthood. They comprise granulomatosis with polyangiitis (GPA, …

Background Juvenile idiopathic arthritis can be refractory to some or all treatment regimens,
therefore new medications are needed to treat this population. This trial assessed the …

Objectives. The annual incidence of ARF ranges from 5 to 51/100 000 population worldwide
in the 5- to 15-year age group. In the past, there was a decline in the incidence of ARF; …

Background Behçet’s disease is a rare multi-systemic inflammatory disease with unknown
etiology which involves principally oral and genital mucosa, skin and eyes. Average age at …

Anti-transglutaminase antibodies are the diagnostic markers of coeliac disease. A role is
suggested for infectious agents in the production of anti-transglutaminase antibodies. The aim …

Objective. Anti-TNF-α agents have significantly changed the management of juvenile idiopathic
arthritis (JIA). We evaluated the safety and efficacy of adalimumab (ADA) and infliximab (…

Background Chronic Non-Bacterial Osteomyelitis (CNO) is an inflammatory disorder that
primarily affects children. Although underestimated, its incidence is rare. For these reasons, no …