Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients

…, PJ Daneel, S Ruff, A Rüter, S Santavirta… - JBJS, 2002 - journals.lww.com
Background: The treatment of open fractures of the tibial shaft is often complicated by delayed
union and nonunion. The objective of this study was to evaluate the safety and efficacy of …

Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis

…, H Ida, J Mandelin, RW Kinne, S Santavirta… - Annals of the …, 1999 - ard.bmj.com
OBJECTIVE To define the pattern of mRNA expression of all human matrix metalloproteinases
(MMPs) described to date in rheumatoid arthritis (RA) and traumatic synovial membrane, …

Failure of reduction with an external fixator in the management of pelvic ring injuries: long-term evaluation of 110 patients

…, O Böstman, S Santavirta - The Journal of Bone & …, 1999 - boneandjoint.org.uk
We reviewed 110 patients with an unstable fracture of the pelvic ring who had been treated
with a trapezoidal external fixator after a mean follow-up of 4.1 years. There were eight open-…

Operative and nonoperative treatments of medial collateral ligament rupture with early anterior cruciate ligament reconstruction: a prospective randomized study

…, E Hirvensalo, S Santavirta - The American journal …, 2006 - journals.sagepub.com
Background The apparent consensus is that solitary medial collateral ligament rupture can
be treated nonoperatively, but treatment of severe combined ruptures of the medial collateral …

Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis

…, M Takagi, I Virtanen, S Santavirta - … : Official Journal of …, 2002 - Wiley Online Library
Objective To measure cartilage pH in patients with osteoarthritis (OA) and to analyze the
presence of cathepsin K, the recently discovered acidic endoproteinase, in phenotypically …

Aggressive granulomatous lesions in cementless total hip arthroplasty

S Santavirta, V Hoikka, A Eskola… - The Journal of Bone …, 1990 - boneandjoint.org.uk
We describe six patients with aggressive granulomatous lesions around cementless total hip
prostheses. Two patients previously had a cemented prosthesis in the same hip. The Lord …

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

…, T Sorsa, Y Ding, S Santavirta… - … : Official Journal of …, 1997 - Wiley Online Library
Objective. To show the eventual presence and extent of production of matrix metalloproteinase
13 (MMP‐13, or collagenase 3) in rheumatoid synovial tissue samples and extracts, and …

Immune response to polyglycolic acid implants

S Santavirta, YT Konttinen, T Saito… - The Journal of Bone …, 1990 - boneandjoint.org.uk
Cytological analysis of material aspirated from the effusion which occasionally develops
around a polyglycolic acid (PGA) osteosynthesis implant showed a predominance of …

Immunohistochemical evaluation of inflammatory mediators in failing implants.

…, P Laine, U Kitti, S Santavirta… - … of Periodontics & …, 2006 - search.ebscohost.com
It was hypothesized that peri-implant tissue around loosening dental implants may contain
cytokines with a potential to regulate osteoclasts. Peri-implant and/or gingival samples from …

The microenvironment around total hip replacement prostheses

…, N Ashammakhi, S Santavirta - Clinical Orthopaedics …, 2005 - journals.lww.com
The metal stem of the totally replaced hip carries load and resists fatigue, but it is
electrochemically corroded. Metallic atoms act as haptens, induce type 1 T-helper cells/Th1-type …