Juvenile idiopathic arthritis (JIA) is the most common chronic arthropathy of childhood which
is believed to be influenced by both genetic and environmental factors. The progress in …

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthropathy of
childhood. Juvenile idiopathic arthritis is believed to be a complex genetic trait influenced by …

Although there are challenges to the identification of genetic factors underlying complex
diseases such as JIA, considerable progress has been made in JIA genetics. Candidate gene …

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To
identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases …

Objective To develop criteria for the classification of macrophage activation syndrome (MAS)
in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process, …

We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …

Background Tofacitinib is an oral Janus kinase inhibitor. This trial assessed the efficacy and
safety of tofacitinib versus placebo in patients with polyarticular course juvenile idiopathic …

Objective There is wide variation in therapeutic approaches to systemic juvenile idiopathic
arthritis (JIA) among North American rheumatologists. Understanding the comparative …

Objective To determine if the prevalence of autoimmunity among relatives of patients with
juvenile rheumatoid arthritis (JRA) is greater than that among relatives of healthy volunteer …

Macrophage activation syndrome (MAS), a recognized complication of systemic juvenile
rheumatoid arthritis (sJRA), has been associated with significant morbidity and mortality. …