Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis
SJ Carmichael, B Charles, SE Tett - Therapeutic drug monitoring, 2003 - journals.lww.com
Hydroxychloroquine (HCQ) is an antimalarial drug that is also used as a second-line treatment
of rheumatoid arthritis (RA). Clinically, the use of HCQ is characterized by a long delay in …
of rheumatoid arthritis (RA). Clinically, the use of HCQ is characterized by a long delay in …
Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate.
OBJECTIVE: To examine the bioavailability of methotrexate (MTX) in the presence of
hydroxychloroquine (HCQ), and vice versa, to determine a possible pharmacokinetic explanation …
hydroxychloroquine (HCQ), and vice versa, to determine a possible pharmacokinetic explanation …
Vancomycin continuous infusion as prophylaxis for vascular surgery
CJ Payne, SJ Carmichael, AT Stearns… - Therapeutic drug …, 2009 - journals.lww.com
Prosthetic graft infection is a devastating complication of vascular surgery that occurs in 3%-5%
of clean prosthetic procedures. Staphylococci are the most frequently isolated pathogens…
of clean prosthetic procedures. Staphylococci are the most frequently isolated pathogens…
[PDF][PDF] Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-…
vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-…
The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity
SARS-CoV-2 can mutate to evade immunity, with consequences for the efficacy of emerging
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …
vaccines and antibody therapeutics. Herein we demonstrate that the immunodominant …
[PDF][PDF] Comprehensive rare variant analysis via whole-genome sequencing to determine the molecular pathology of inherited retinal disease
…, L Allen, R Armstrong, AF Brady, J Carmichael… - The American Journal of …, 2017 - cell.com
Inherited retinal disease is a common cause of visual impairment and represents a highly
heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals …
heterogeneous group of conditions. Here, we present findings from a cohort of 722 individuals …
Neoadjuvant intravenous oncolytic vaccinia virus therapy promotes anticancer immunity in patients
A Samson, EJ West, J Carmichael, KJ Scott… - Cancer immunology …, 2022 - AACR
… Clones were defined by having the same TCRBV/J segment and identical CDR3 sequence,
and their abundance was adjusted using the absolute T-cell count to eliminate amplification …
and their abundance was adjusted using the absolute T-cell count to eliminate amplification …
Development of a human liver microphysiological co-culture system for higher throughput chemical safety assessment
…, H Li, S Martin, S Spriggs, P Carmichael… - Toxicological …, 2024 - academic.oup.com
Chemicals in the systemic circulation can undergo hepatic xenobiotic metabolism, generate
metabolites and exhibit altered toxicity compared to their parent compounds. This paper …
metabolites and exhibit altered toxicity compared to their parent compounds. This paper …
Epidemic waves of COVID-19 in Scotland: a genomic perspective on the impact of the introduction and relaxation of lockdown on SARS-CoV-2
…, K Smollett, D Mair, S Carmichael, L Tong, J Nichols… - MedRxiv, 2021 - medrxiv.org
The second SARS virus, SARS-CoV-2, emerged in December 2019, and within a month was
globally distributed. It was first introduced into Scotland in February 2020 associated with …
globally distributed. It was first introduced into Scotland in February 2020 associated with …
[HTML][HTML] Using selfies to challenge public stereotypes of scientists
In an online Qualtrics panel survey experiment (N = 1620), we found that scientists posting
self-portraits (“selfies”) to Instagram from the science lab/field were perceived as significantly …
self-portraits (“selfies”) to Instagram from the science lab/field were perceived as significantly …