Airway inflammation in severe asthma is not well characterized but may involve neutrophils.
We have compared induced sputum profiles in patients with asthma of varying severity and …

The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown,
but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling …

Exacerbations of asthma are likely to be due to an increase in airway inflammation. We have
studied noninvasive markers of airway inflammation in asthma exacerbations induced by …

Background and aims We studied damage accrual and factors determining development
and progression of damage in an international cohort of systemic lupus erythematosus (SLE) …

Peroxynitrite is a potent oxidant formed by the rapid reaction of the free radicals nitric oxide (NO)
and superoxide. It causes airway hyperresponsiveness and airway epithelial damage, …

We determined the effect of inhaled corticosteroid, budesonide, on the release of the anti-inflammatory
cytokine, interleukin-10 (IL-10), and of pro-inflammatory cytokines, macrophage …

Asthma is a chronic inflammatory disease that is characterized by increased expression of
multiple inflammatory genes. Chromatin modification plays a critical role in the regulation of …

An imbalance between proteases and antiproteases may play a role in emphysema, which is
characterized by increased degradation of extracellular matrix, and in airway remodeling in …

Background: Protease-activated receptors (PARs), which are G protein–coupled receptors
that are activated after proteolytic cleavage of the amino terminus of the receptor, are likely to …

Oxidative stress contributes to airway inflammation and exhaled hydrogen peroxide (H 2 O
2 ) and nitric oxide (NO) are elevated in asthmatic patients. We determined the …