Objective Sjögren's syndrome (SS) is an autoimmune disorder characterized by dry eyes
and mouth (sicca syndrome) and lymphocytic infiltration of the lacrimal and salivary glands. …

Background & Aims: Defects in enteric excitatory neurotransmission have been proposed to
underlie the gastrointestinal dysmotility associated with scleroderma (systemic sclerosis). …

Secretions from salivary and lacrimal glands are reduced in patients with primary Sjögren's
syndrome (PSS). Since aquaporin 5 is involved in transport of water and is present in …

Salivary and lacrimal gland secretions are reduced in primary Sjögren's syndrome (pSS).
Aquaporins (AQPs) are involved in transmembrane water transport, and different isoforms …

M3-muscarinic receptors (M3R) mediate parasympathetic cholinergic neurotransmission to
salivary and lacrimal glands, and autoantibodies to these receptors have been implicated in …

Somatic muscle weakness and autonomic symptoms characterize the autoimmune Lambert‐Eaton
myasthenic syndrome (LEMS). The former results from IgG autoantibody–mediated …

Little is known about the intrinsic enteric reflex pathways associated with migrating motor
complex (MMC) formation. Acetylcholine (ACh) mediates the rapid component of the MMC, …

Objective. The presence, in patients with primary and secondary Sjögren’s syndrome (SS),
of autoantibodies that acutely inhibit M3 muscarinic receptor (M3R)–mediated bladder …

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by
muscle wakness and autonomic dysfunction. Recentex vivo andin vitro studies demonstrate …

Functional antimuscarinic M3 receptor (M3R) autoantibodies have been shown to inhibit
cholinergic neurotransmission at the postsynaptic level and appear to mediate parasympathetic …