User profiles for Said Kamel
said Kamelprofesseur de biochimie Verified email at u-picardie.fr Cited by 7324 |
Vascular calcification: from pathophysiology to biomarkers
The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered, …
Over time, as clinical importance of this phenomenon has begun to be fully considered, …
Agonists and allosteric modulators of the calcium-sensing receptor and their therapeutic applications
The calcium-sensing receptor (CaR) belongs to the G protein-coupled receptor superfamily,
with a characteristic structure consisting of seven transmembrane helices, an intracellular C-…
with a characteristic structure consisting of seven transmembrane helices, an intracellular C-…
Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptor-stimulated MCF-7 breast cancer cell proliferation
…, F Hague, F Gouilleux, R Mentaverri, S Kamel… - Cellular Physiology and …, 2009 - karger.com
The calcium-sensing receptor (CaR), is a G protein-dependent receptor that responds to
increments in extracellular Ca 2+ ([Ca 2+ ] o ). We previously reported that an increase in [Ca 2…
increments in extracellular Ca 2+ ([Ca 2+ ] o ). We previously reported that an increase in [Ca 2…
[HTML][HTML] The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis: new insights into the associated signaling pathways
…, A Caudrillier, F Cournarie, A Wattel, S Kamel… - Journal of Biological …, 2009 - ASBMB
Strontium ranelate exerts both an anti-catabolic and an anabolic effect on bone cells. To further
investigate the molecular mechanism whereby strontium ranelate inhibits bone resorption…
investigate the molecular mechanism whereby strontium ranelate inhibits bone resorption…
Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NFκB and AP‐1
A Wattel, S Kamel, C Prouillet, JP Petit… - Journal of cellular …, 2004 - Wiley Online Library
Flavonoids are micronutrients widely present in food of plant origin. They have been attributed
pharmacological properties such as anticancer and prevention of age‐related pathologies…
pharmacological properties such as anticancer and prevention of age‐related pathologies…
Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption
A Wattel, S Kamel, R Mentaverri, F Lorget… - Biochemical …, 2003 - Elsevier
Several recent studies have suggested that flavonols, a class of phytochemicals with many
biological activities, might exert a protective effect against post-menopausal bone loss. In the …
biological activities, might exert a protective effect against post-menopausal bone loss. In the …
Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen …
…, C Mazière, A Wattel, M Brazier, S Kamel - Biochemical …, 2004 - Elsevier
Many plant-derived substances have estrogenic activities. Due to their ability to bind the
estrogen receptor (ER), these compounds have the potential to counteract the deleterious …
estrogen receptor (ER), these compounds have the potential to counteract the deleterious …
Low-gradient, low-flow severe aortic stenosis with preserved left ventricular ejection fraction: characteristics, outcome, and implications for surgery
…, N Debry, J Maizel, R Mentaverri, S Kamel… - Journal of the American …, 2015 - jacc.org
Background : Severe low-gradient, low-flow (LG/LF) aortic stenosis with preserved left
ventricular ejection fraction (EF) has been described as a more advanced form of aortic stenosis. …
ventricular ejection fraction (EF) has been described as a more advanced form of aortic stenosis. …
High extracellular calcium concentrations directly stimulate osteoclast apoptosis
F Lorget, S Kamel, R Mentaverri, A Wattel… - Biochemical and …, 2000 - Elsevier
Although the inhibitory effects of high extracellular calcium concentrations ([Ca] e ) on
osteoclastic bone resorption have been known for several years, the exact mechanism remains …
osteoclastic bone resorption have been known for several years, the exact mechanism remains …
High extracellular inorganic phosphate concentration inhibits RANK–RANKL signaling in osteoclast‐like cells
…, R Mentaverri, P Morlière, S Kamel… - Journal of cellular …, 2008 - Wiley Online Library
In this work, we investigated the effect of inorganic phosphate (Pi) on the differentiation of
monocyte/macrophage precursors into an “osteoclastic” phenotype, and we delineated the …
monocyte/macrophage precursors into an “osteoclastic” phenotype, and we delineated the …