Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…

Objectives Systemic sclerosis (SSc) is an autoimmune disease characterised by skin and
systemic fibrosis culminating in organ damage. Previous genetic studies including genome-…

Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation.
We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese …

Objectives: To compare disease activity and the improvement of disease activity evaluated
between by Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28-ESR) …

In this review, recent changes in both treatments and outcomes of rheumatoid arthritis (RA)
in Japan were analyzed by viewing the National Database of Rheumatic Diseases by iR-net, …

The proteasome activator PA28 binds to both ends of the central catalytic machine, known as
the 20 S proteasome, in opposite orientations to form the enzymatically active proteasome. …

Objective. To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-modifying
antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients …

Objective To evaluate the efficacious noninferiority of subcutaneous tocilizumab injection (TCZ‐SC)
monotherapy to intravenous TCZ infusion (TCZ‐IV) monotherapy in Japanese …

Objectives To investigate the duration of remission and low disease activity (LDA) after cessation
of tocilizumab (TCZ) treatment in rheumatoid arthritis patients who showed remission or …