IL-17 is a newly discovered T cell–derived cytokine whose role in osteoclast development has
not been fully elucidated. Treatment of cocultures of mouse hemopoietic cells and primary …

Osteoclast differentiation factor (ODF, also called RANKL/TRANCE/OPGL) stimulates the
differentiation of osteoclast progenitors of the monocyte/macrophage lineage into osteoclasts in …

Objective To elucidate the direct role of human T cells in the induction of osteoclastogenesis
in rheumatoid arthritis (RA), by studying human monocytes and the pathogenetic roles of …

Chronic immune responses and inflammatory reactions in rheumatoid arthritis (RA) often
cause severe destruction of cartilage and bone, but its mechanism is still a matter of controversy…

IL‐17 is a proinflammatory cytokine crucial for osteoclastic bone resorption in the presence
of osteoblasts or synoviocytes in rheumatoid arthritis. However, the role of IL‐17 in …

This study demonstrates that IL-23 stimulates the differentiation of human osteoclasts from
peripheral blood mononuclear cells (PBMC). Furthermore, in vivo blockade of endogenous IL-…

The current study explored our hypothesis that IFN‐γ‐producing human T cells inhibit human
osteoclast formation. Activated T cells derived from human PBMC were divided into IFN‐γ‐…

Bone-resorbing osteoclasts are formed from hemopoietic cells of the monocyte–macrophage
lineage under the control of bone-forming osteoblasts. We have cloned an osteoblast-…

Helper T (Th) cells play an important role in the pathogenesis of autoimmune diseases,
including rheumatoid arthritis (RA). It has been revealed that Th17 cells can shift to Th1 cells (ie, “…

Many papers have reported that osteoclasts play an important role in the pathogenesis of
rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the …